2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Sigma Receptor
  4. SKF 83959 hydrobromide

SKF 83959 hydrobromide 

目录号: HY-103412 纯度: 99.86%
COA 产品使用指南

摩尔计算器

SKF83959 hydrobromide 是一种有效的选择性多巴胺 D1-like 受体部分激动剂。 SKF83959 hydrobromide Ki 对大鼠 D1，D5，D2 和 D3 的值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 hydrobromide 是一种有效的 sigma (σ)-1 受体变构调节剂。SKF83959 hydrobromide 属于 benzazepine 家族，对认知功能障碍有改善作用。SKF83959 hydrobromide 可用于研究阿尔茨海默病和抑郁症。

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SKF 83959 hydrobromide Chemical Structure

SKF 83959 hydrobromide Chemical Structure

CAS No. : 67287-95-0

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规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg ￥5000
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50 mg   询价  

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Customer Review

Other Forms of SKF 83959 hydrobromide:

SKF 83959 hydrobromide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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Sigma 1 Receptor Sigma 2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SKF83959 hydrobromide is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 hydrobromide Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression[1][2][3][4].

IC50 & Target[3][4]

D1 Receptor

1.18 nM (Ki)

D5 Receptor

7.56 nM (Ki)

D2 Receptor

920 nM (Ki)

D3 Receptor

399 nM (Ki)

sigma (σ)-1

 

体外研究
(In Vitro)

SKF83959 hydrobromide (10~250 μM) stimulates PIP2 hydrolysis in membranes. SKF83959 hydrobromide (0.1~10 μM; PC12 cell) changes the EC50 value of SKF81297 from 0.5 nM in control tissue to 31.6 nM, 251.2 nM and 631.0 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SKF 83959 hydrobromide 相关抗体:
体内研究
(In Vivo)

SKF83959 hydrobromide (0.5 and 1 mg/kg; i.p.; 1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test[1].
SKF83959 hydrobromide (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade[1].
SKF83959 hydrobromide has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR male mice (8 weeks)[1]
Dosage: 0.5 and 1 mg/kg
Administration: I.p.; 1 hour
Result: Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
Animal Model: Male ICR male mice (8 weeks)[1]
Dosage: 1 mg/kg
Administration: I.p.; 30 minutes
Result: The memory enhancing effects were prevented by BDNF system blockade.
分子量

398.72

Formula

C18H21BrClNO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (50.16 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

DMF 中的溶解度 : 20 mg/mL (50.16 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5080 mL 12.5401 mL 25.0803 mL
5 mM 0.5016 mL 2.5080 mL 5.0161 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.86%

COA (290 KB) LCMS (110 KB) 元素分析报告 (213 KB)

产品使用指南 (1538 KB)
参考文献

SKF 83959 hydrobromide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 2.5080 mL 12.5401 mL 25.0803 mL 62.7006 mL
5 mM 0.5016 mL 2.5080 mL 5.0161 mL 12.5401 mL
10 mM 0.2508 mL 1.2540 mL 2.5080 mL 6.2701 mL
15 mM 0.1672 mL 0.8360 mL 1.6720 mL 4.1800 mL
20 mM 0.1254 mL 0.6270 mL 1.2540 mL 3.1350 mL
25 mM 0.1003 mL 0.5016 mL 1.0032 mL 2.5080 mL
30 mM 0.0836 mL 0.4180 mL 0.8360 mL 2.0900 mL
40 mM 0.0627 mL 0.3135 mL 0.6270 mL 1.5675 mL
50 mM 0.0502 mL 0.2508 mL 0.5016 mL 1.2540 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 8395967287-95-0SKF83959SKF-83959Dopamine ReceptorSigma ReceptorPC12PIP2hydrolysisdopaminebenzazepinecognitivedysfunctionAlzheimerInhibitorinhibitorinhibit

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目录号：
HY-103412
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