2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Spisulosine

Spisulosine (ES-285) 是一种海洋来源的抗增殖（抗肿瘤）化合物。 Spisulosine 通过细胞内神经酰胺积累和 PKCζ 激活抑制前列腺 PC-3 和 LNCaP 细胞的生长。

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Spisulosine Chemical Structure

Spisulosine Chemical Structure

CAS No. : 196497-48-0

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规格 价格 是否有货 数量
1 mg ￥2466
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Other Forms of Spisulosine:

Spisulosine 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation[1].

IC50 & Target[1]

PKCζ

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HBL-100 GI50
2.3 μM
Compound: 1
Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human HBL100 cells after 48 hrs incubation by SRB assay
[PMID: 25899335]
HeLa GI50
2.6 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs incubation by SRB assay
[PMID: 25899335]
LNCaP IC50
1 μM
Compound: 3; ES-285
Cytotoxicity against human LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31926468]
PC-3 IC50
1 μM
Compound: 3; ES-285
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31926468]
SW1573 GI50
1.3 μM
Compound: 1
Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human SW1573 cells after 48 hrs incubation by SRB assay
[PMID: 25899335]
T47D GI50
0.9 μM
Compound: 1
Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human T47D cells after 48 hrs incubation by SRB assay
[PMID: 25899335]
WiDr GI50
0.7 μM
Compound: 1
Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay
Antiproliferative activity against human WiDr cells after 48 hrs incubation by SRB assay
[PMID: 25899335]
分子量

285.51

Formula

C18H39NO
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Spisula polynyma
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (7.01 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5025 mL 17.5125 mL 35.0250 mL
5 mM 0.7005 mL 3.5025 mL 7.0050 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.00%

COA (276 KB)

产品使用指南 (1538 KB)
参考文献

Spisulosine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5025 mL 17.5125 mL 35.0250 mL 87.5626 mL
5 mM 0.7005 mL 3.5025 mL 7.0050 mL 17.5125 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spisulosine196497-48-0ES-285ES285ES 285PKCProtein kinase Cceramide accumulationantitumoralPKCζInhibitorinhibitorinhibit

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