2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. STAMBP-IN-1

STAMBP-IN-1 是 STAMBP去泛素酶的小分子抑制剂，能中断 STAMBP-Ub-NALP7 的相互作用。在 Toll 样受体 (TLR) 激动后，STAMBP-IN-1 能够降低炎性小体底物 NALP7 的蛋白水平，抑制 IL-1b 释放。STAMBP- in -1 抑制了 STAMBP 裂解重组蛋白 di-Ub 的活性，IC50 为 0.33 mM。

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STAMBP-IN-1 Chemical Structure

STAMBP-IN-1 Chemical Structure

CAS No. : 896683-78-6

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规格 价格 是否有货 数量
1 mg ￥816
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5 mg ￥2000
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10 mg ￥3200
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25 mg ￥5563
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Customer Review

STAMBP-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Deubiquitinase 亚型特异性产品:

查看所有亚型
USP1 USP2 USP7 USP8 USP30 UCHL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC50 value of 0.33 mM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf21 IC50
0.33 μM
Compound: BC-1471
Inhibition of human STAMBP expressed in Sf21 cells pre-incubated for 20 mins before Ubiquitinated NALP7 substrate addition and measured after 1 hr by immunoblotting analysis
Inhibition of human STAMBP expressed in Sf21 cells pre-incubated for 20 mins before Ubiquitinated NALP7 substrate addition and measured after 1 hr by immunoblotting analysis
[PMID: 31682427]
体外研究
(In Vitro)

STAMBP-IN-1 (0.1-10 μM; 6 h) exhibits the most potent ability to selectively decrease NALP7 abundance as well as endogenous NALP7 abundance in THP-1 cells, but not NALP6[1].
STAMBP-IN-1 (0.01-100 μM; 37 ℃; 2 h) inhibits cleavage of K63-linked di-Ub (200 nM) to mono-Ub by purified recombinant STAMBP (25 nM) in a concentration dependent manner[1].
STAMBP-IN-1 (0.01-10 μM; 37 ℃; 60 min) blocks STAMBP mediated deubiquitination of Ub-NALP7 in vitro in a concentration-dependent manner[1].
STAMBP-IN-1 exhibits toxicity against THP-1 cells with an IC50 of 106 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAMBP-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: THP-1 cells
Concentration: 0.01, 0.1, 1, 10, and 100 μM
Incubation Time: 6 hours
Result: Inhibited the activity of STAMBP to cleave recombinant di-Ub in a concentrationdependent manner with an IC50 of 0.33 mM (0.09-1.21 mM).
分子量

504.60

Formula

C27H28N4O4S
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3.29 mg/mL (6.52 mM; warming and heat to 80°C; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9818 mL 9.9088 mL 19.8177 mL
5 mM 0.3964 mL 1.9818 mL 3.9635 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

STAMBP-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9818 mL 9.9088 mL 19.8177 mL 49.5442 mL
5 mM 0.3964 mL 1.9818 mL 3.9635 mL 9.9088 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAMBP-IN-1896683-78-6DeubiquitinaseDUBsdeubiquitinaseNALP7Toll-like receptor,TLRrecombinant di-UbInhibitorinhibitorinhibit

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目录号：
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