2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Treprostinil diethanolamine

Treprostinil diethanolamine  (Synonyms: 曲前列尼尔二乙醇胺; UT-15C)

目录号: HY-B0813 纯度: 99.44%
COA 产品使用指南

摩尔计算器

Treprostinil diethanolamine (UT-15C) 是一种有效的 EP2、DP1 和 IP 激动剂，对 EP2、DP1、IP、EP1、EP4、EP3 和 FP 的 Ki 值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 增加 cAMP 的上调，从而维持血管系统内的动态平衡。Treprostinil diethanolamine 可导致人肺动脉的血管扩张。

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Treprostinil diethanolamine Chemical Structure

Treprostinil diethanolamine Chemical Structure

CAS No. : 830354-48-8

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规格 价格 是否有货 数量
1 mg ￥1260
In-stock
5 mg ￥3420
In-stock
10 mg ￥5100
In-stock
25 mg 现货 询价
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100 mg   询价  

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Customer Review

Other Forms of Treprostinil diethanolamine:

Treprostinil diethanolamine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries[1][2][3].

IC50 & Target[1]

DP1

4.4 nM (Ki)

EP1

212 nM (Ki)

EP4

826 nM (Ki)

EP3

2505 nM (Ki)

IP

32.1 nM (Ki)

FP

4680 nM (Ki)

EP2

3.6 nM (Ki)

体外研究
(In Vitro)

Treprostinil diethanolamine (UT-15C; 0.001-10,000 nM; 60 min; HEK293 cells) has high potency in activating DP1 and EP2 receptors as well as the IP receptor with EC50 values of 0.6 nM, 6.2 nM and 1.9 nM, respectively, 36-fold less active at the EP3 receptor, 95-fold less active at the EP4 and 150-fold less active at the EP1 site than at the IP receptor[1].
Treprostinil diethanolamine (10 μM) increases cAMP accumulation in murine and human hematopoietic stem and progenitor cells (HSPCs) [2].
Treprostinil diethanolamine (10 μM; 2-6 h; PC3 cells) enhances the action of SDF-1 via CXCR4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Treprostinil diethanolamine 相关抗体:
体内研究
(In Vivo)

Treprostinil diethanolamine (UT-15C; 0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) enhances the ability of HSPCs to repopulate the bone marrow and increases bone marrow reconstitution[2].
Treprostinil diethanolamine (0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) increases survival of lethally irradiated recipient mice[2].
Treprostinil diethanolamine (0.1 mg/kg; i.h.; for 24h; male lewis rats) inhibits the mRNA expression of TNF-α and IFN-γ and increases in IL-10 expression[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[2]
Dosage: 0.15 mg/kg
Administration: Subcutaneous injection; every 8 hours; for 10 days
Result: Increased survival of lethally irradiated recipient mice.
Animal Model: Male lewis rats[3]
Dosage: 0.1 mg/kg
Administration: Subcutaneous injection; for 24 hours
Result: Decreased the mRNA expression of TNF-α and IFN-γ and increased the expression of IL-10.
Clinical Trial
分子量

495.65

Formula

C27H45NO7
CAS 号
性状

固体

颜色

White to off-white

中文名称

曲前列尼尔二乙醇胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (252.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0176 mL 10.0878 mL 20.1755 mL
5 mM 0.4035 mL 2.0176 mL 4.0351 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Treprostinil diethanolamine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0176 mL 10.0878 mL 20.1755 mL 50.4388 mL
5 mM 0.4035 mL 2.0176 mL 4.0351 mL 10.0878 mL
10 mM 0.2018 mL 1.0088 mL 2.0176 mL 5.0439 mL
15 mM 0.1345 mL 0.6725 mL 1.3450 mL 3.3626 mL
20 mM 0.1009 mL 0.5044 mL 1.0088 mL 2.5219 mL
25 mM 0.0807 mL 0.4035 mL 0.8070 mL 2.0176 mL
30 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.6813 mL
40 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2610 mL
50 mM 0.0404 mL 0.2018 mL 0.4035 mL 1.0088 mL
60 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8406 mL
80 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5044 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Treprostinil diethanolamine830354-48-8UT-15C曲前列尼尔二乙醇胺Prostaglandin ReceptorcAMPvasculaturepulmonary arteriesHEK293 cellsCXCR4Inhibitorinhibitorinhibit

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