2. Cell Cycle/DNA Damage Cytoskeleton Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Microtubule/Tubulin Reactive Oxygen Species Apoptosis
  4. Tubulin polymerization-IN-67

Tubulin polymerization-IN-67 (Compound 5h) 是秋水仙碱结合位点上微管蛋白聚合的抑制剂，IC50 为 2.92 μM。Tubulin polymerization-IN-67 抑制癌细胞 HT29、A549、U2OS、MG-63 和 HeLa 的增殖，IC50为 0.12-4.13 μM。Tubulin polymerization-IN-67 在 G2/M 期阻滞细胞周期，诱导 U2OS 细胞凋亡 (apoptosis)，抑制 A549 的细胞迁移。Tubulin polymerization-IN-67 降低线粒体膜电位 (MMP) 并增加细胞内 ROS，抑制 HUVEC 中的血管生成。Tubulin polymerization-IN-67 在小鼠中表现出抗肿瘤活性。

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Tubulin polymerization-IN-67 Chemical Structure

Tubulin polymerization-IN-67 Chemical Structure

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Tubulin polymerization-IN-67 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-67 (Compound 5h) is an inhibitor for tubulin polymerization on colchicine binding site with an IC50 of 2.92 μM. Tubulin polymerization-IN-67 inhibits the proliferation of cancer cells HT29, A549, U2OS, MG-63 and HeLa with IC50s of 0.12-4.13 μM. Tubulin polymerization-IN-67 arrests the cell cycle at G2/M phase, induces apoptosis in cell U2OS, inhibits the cell migration of A549. Tubulin polymerization-IN-67 reduces the mitochondrial membrane potential (MMP) and increase intracellular ROS, inhibits the angiogenesis in HUVECs. Tubulin polymerization-IN-67 exhibits antitumor efficacy in mice[1]

分子量

422.47

Formula

C24H26N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-67 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-67Microtubule/TubulinReactive Oxygen SpeciesApoptosisHT29A549U2OSMG-63HeLaHUVECsBALB/c mouseInhibitorinhibitorinhibit

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