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TX-2552 是一种口服有效的酪氨酰 DNA 磷酸二酯酶 1 (TDP1) 抑制剂，IC50 值为 0.62 μM。TX-2552 可以增强拓扑替康 (HY-13768) 在小鼠骨髓细胞中的致裂活性，也可以增强拓扑替康 (HY-13768) 在 Krebs-2 腹水瘤小鼠中的抗肿瘤作用。

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TX-2552 Chemical Structure

TX-2552 Chemical Structure

CAS No. : 2446767-14-0

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TX-2552 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice[1][2].
IC50 & Target

TDP1[1].
体内研究
(In Vivo)

TX-2552 (20-160 mg/kg; 口服) 可以在骨髓细胞染色体畸变小鼠中增强拓扑替康 (HY-13768) 的致裂作用[1]。
TX-2552 (20-120 mg/kg; 每天 1 次; 18 天; 腹腔注射) 可以增强拓扑替康 (HY-13768) 在 Krebs-2 腹水瘤小鼠中的抗肿瘤作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chromosomal aberration mouse model[1].
Dosage: 20-160 mg/kg
Administration: Oral gavage (p.o.) (Topotecan administered intraperitoneally at single doses of 0.25, 0.5, and 1 mg/kg induced chromosomal aberrations in bone marrow cells of F1(CBA×C57BL/6) hybrid mice in a dose-dependent manner)
Result: Increased the level of aberrant metaphases induced by Topotecan (0.25 mg/kg) by 2.1-2.6 times.
Animal Model: Krebs-2 ascites tumor female C57BL/6 mice model[2].
Dosage: 20-120 mg/kg
Administration: Intraperitoneal injection (i.p.); once daily; 18 days (injected ascites cells intraperitoneally on day zero)
Result: Reduced tumor volume and extended mouse lifespan.
分子量

392.46

Formula

C25H25FO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TX-2552 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX-25522446767-14-0TX2552TX 2552OthersTopotecanchromosomemarrow cellsInhibitorinhibitorinhibit

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