2. Apoptosis
  3. Apoptosis
  4. USP10-IN-3

USP10-IN-3 (compound D1) 是一种有效的 USP10 抑制剂，其 IC50 值为 7.2 µM。USP10-IN-3 可抑制细胞增殖。USP10-IN-3 可诱导细胞凋亡 (apoptosis) 和细胞周期停滞于 S 期。

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USP10-IN-3 Chemical Structure

USP10-IN-3 Chemical Structure

CAS No. : 3059565-11-3

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规格 价格 是否有货
1 mg ￥2100
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5 mg ￥5350
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10 mg 现货 询问价格 & 货期
25 mg 现货 询问价格 & 货期

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USP10-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase[1].

IC50 & Target

IC50: 7.2 µM (USP10)[1]
体外研究
(In Vitro)

USP10-IN-3 (compound D1) (0-100 µM) 抑制细胞增殖，对 Huh-7 细胞的 IC50 值为 2.3 µM[1]。
USP10-IN-3 (compound D1) (0-10 µM; 24 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 S 期[1]。
USP10-IN-3 (compound D1) (0-30 µM; 24 h) 以剂量依赖性方式降低 YAP1、p53、p21 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

USP10-IN-3 相关抗体:

Apoptosis Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0, 0.625, 1.25, 2.5, 5, 10 µM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0, 0.625, 1.25, 2.5, 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at S-phase.

Western Blot Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0, 0.37, 1.1, 3.3, 10, 30 µM
Incubation Time: 24 h
Result: Decreased the expression of YAP1, p53, p21 in a dose-dependent manner.
分子量

512.99

Formula

C29H25ClN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

USP10-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

USP10-IN-33059565-11-3ApoptosisHuh-7 cellsapoptosisS-phaseanti-proliferationYAP1p53p21Inhibitorinhibitorinhibit

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USP10-IN-3
目录号：
HY-163622
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