2. Stem Cell/Wnt Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection Neuronal Signaling Apoptosis Metabolic Enzyme/Protease
  3. Organoid HDAC Autophagy Mitochondrial Metabolism HIV Notch Apoptosis Endogenous Metabolite
  4. Valproic acid

Valproic acid  (Synonyms: 丙戊酸 (GMP); Dipropylacetic acid)

目录号: HY-10585G
产品使用指南

摩尔计算器

Valproic acid (GMP) 是 GMP 级别的 Valproic acid (HY-10585)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Valproic acid (VPA) 是一种具有口服活性的 HDAC 抑制剂，IC50 值为 0.5-2 mM。 Valproic acid 抑制 HDAC1 的活性，(IC50，400 μM)，同时可诱导 HDAC2 的降解。Valproic acid 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍、代谢疾病、HIV 感染和偏头痛等的研究。

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Valproic acid Chemical Structure

Valproic acid Chemical Structure

CAS No. : 99-66-1

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Valproic acid 的其他形式现货产品:

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Other Forms of Valproic acid:

Valproic acid 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 36 篇科研文献

WB

    Valproic acid purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2020 Jun 17.  [Abstract]

    Effects of Butyrate (But, 1 mM), Vpa (5 mM) and SAHA (Vor, 1 μM) on the expression of P-gp and BCRP, NF-кB p65 and phosphorylated p65 (p-p65), and IкBα and phosphorylated IкBα (p-IкBα).

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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    HIV HIV-1 HIV-2

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Valproic acid (GMP) is Valproic acid (HY-10585) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].

    IC50 & Target[5][6]

    HDAC1

    400 μM (IC50)

    HDAC

    0.5-2 mM (IC50)

    HDAC2

     

    Autophagy

     

    Mitophagy

     

    分子量

    144.21

    Formula

    C8H16O2
    CAS 号
    中文名称

    丙戊酸 (GMP)
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Valproic acid 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Valproic acid (GMP)99-66-1Dipropylacetic acid (GMP)丙戊酸 (GMP)OrganoidHDACAutophagyMitochondrial MetabolismHIVNotchApoptosisEndogenous MetaboliteHistone deacetylasesHuman immunodeficiency virusproteasomaldegradationNotch1SCLCepilepsybipolar disordermigraineheadachessmall cell lung canceranticanceranticonvulsanthepatic fat accumulationInhibitorinhibitorinhibit

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