2. GPCR/G Protein Immunology/Inflammation
  3. Protease Activated Receptor (PAR) P-selectin
  4. VU0652925

VU0652925 是 BMS986120 的类似物，是一种 PAR4 拮抗剂，对 PAC1 和 P-selectin 的 IC50 值分别为 43 pM 和 39.2 pM。VU0652925 能够抑制 GPIIbIIIa 的活化。

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VU0652925 Chemical Structure

VU0652925 Chemical Structure

CAS No. : 1476847-58-1

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VU0652925 相关抗体

Top Publications Citing Use of Products

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

查看所有亚型
PAR1 PAR2 PAR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Platelet IC50
4.7 nM
Compound: 18
Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay
Antiplatelet activity in human platelet-rich plasma assessed as inhibition of gamma thrombin induced platelet aggregation preincubated for 5 mins followed by gamma thrombin addition and measured upto 15 mins by plate reader assay
[PMID: 35729784]
分子量

490.55

Formula

C24H18N4O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU0652925 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU06529251476847-58-1VU 0652925VU-0652925Protease Activated Receptor (PAR)P-selectinThrombin receptorsCD62PAR4GPIIbIIIaInhibitorinhibitorinhibit

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产品名称：
VU0652925
目录号：
HY-119158
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