2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydrofolate reductase (DHFR) Parasite
  4. WR99210

WR99210  (Synonyms: BRL 6231 free base)

目录号: HY-116387 纯度: 98.72%
COA 产品使用指南

摩尔计算器

WR99210 是一种口服有效的、低毒的二氢叶酸还原酶 (DHFR) 抑制剂 (IC50<0.075 nM)。WR99210 具有较好的抗寄生虫活性，能有效抑制间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine (HY-18062) 的恶性疟原虫株) 以及弓形虫。

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WR99210 Chemical Structure

WR99210 Chemical Structure

CAS No. : 47326-86-3

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥1687
In-stock
10 mg ￥2700
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of WR99210:

WR99210 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3].

IC50 & Target

IC50: <0.075 nM (DHFR)[3].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero IC50
> 1 μM
Compound: WR99210
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 32294614]
Vero IC50
> 10 μM
Compound: WR99210
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
[PMID: 34624822]
体外研究
(In Vitro)

WR99210（0-100 nM；92小时）在组织培养中对刚地弓形虫速殖子具有高度疗效[1]。
WR99210（0-100 nM；92小时）对人包皮成纤维细胞显示出低细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WR99210 相关抗体:

Cell Viability Assay[1]

Cell Line: Human foreskin fibroblasts (T. gondii-infected)
Concentration: 0-100 nM
Incubation Time: 92 h
Result: Showed marked inhibition of T. gondii, with an IC50 value of approximately 50 nM.

Cell Cytotoxicity Assay[1]

Cell Line: Human foreskin fibroblasts
Concentration: 0-100 nM
Incubation Time: 92 h
Result: Lacked of toxicity for fibroblasts.
体内研究
(In Vivo)

WR99210（1.25 mg/kg；腹腔注射；每天一次，连续5天）在小鼠模型中对刚地弓形虫速殖子具有高度疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (T. gondii-infected)[1].
Dosage: 1.25 mg/kg
Administration: Intraperitoneal injection; single daily for 5 days.
Result: Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.
分子量

394.68

Formula

C14H18Cl3N5O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (12.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5337 mL 12.6685 mL 25.3370 mL
5 mM 0.5067 mL 2.5337 mL 5.0674 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.72%

COA (193 KB) LCMS (279 KB)

产品使用指南 (1538 KB)
参考文献

WR99210 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5337 mL 12.6685 mL 25.3370 mL 63.3425 mL
5 mM 0.5067 mL 2.5337 mL 5.0674 mL 12.6685 mL
10 mM 0.2534 mL 1.2668 mL 2.5337 mL 6.3342 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WR9921047326-86-3BRL 6231WR 99210WR-99210BRL6231BRL-6231Dihydrofolate reductase (DHFR)ParasiteP. falciparumparasitetoxoplasma gondiiT. gondiiInhibitorinhibitorinhibit

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目录号：
HY-116387
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