2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydrofolate reductase (DHFR) Parasite
  4. WR99210

WR99210  (Synonyms: BRL 6231 free base)

目录号: HY-116387 纯度: 98.72%
COA 产品使用指南

摩尔计算器

WR99210 是一种口服有效的、低毒的二氢叶酸还原酶 (DHFR) 抑制剂 (IC50<0.075 nM)。WR99210 具有较好的抗寄生虫活性，能有效抑制间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine (HY-18062) 的恶性疟原虫株) 以及弓形虫。

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WR99210 Chemical Structure

WR99210 Chemical Structure

CAS No. : 47326-86-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥1687
In-stock
10 mg ￥2700
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of WR99210:

WR99210 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3].

IC50 & Target

IC50: <0.075 nM (DHFR)[3].
体外研究
(In Vitro)

WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture[1].
WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WR99210 相关抗体:

Cell Viability Assay[1]

Cell Line: Human foreskin fibroblasts (T. gondii-infected)
Concentration: 0-100 nM
Incubation Time: 92 h
Result: Showed marked inhibition of T. gondii, with an IC50 value of approximately 50 nM.

Cell Cytotoxicity Assay[1]

Cell Line: Human foreskin fibroblasts
Concentration: 0-100 nM
Incubation Time: 92 h
Result: Lacked of toxicity for fibroblasts.
体内研究
(In Vivo)

WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (T. gondii-infected)[1].
Dosage: 1.25 mg/kg
Administration: Intraperitoneal injection; single daily for 5 days.
Result: Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.
分子量

394.68

Formula

C14H18Cl3N5O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (12.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5337 mL 12.6685 mL 25.3370 mL
5 mM 0.5067 mL 2.5337 mL 5.0674 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.72%

COA (193 KB) LCMS (279 KB)

产品使用指南 (1538 KB)
参考文献

WR99210 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5337 mL 12.6685 mL 25.3370 mL 63.3425 mL
5 mM 0.5067 mL 2.5337 mL 5.0674 mL 12.6685 mL
10 mM 0.2534 mL 1.2668 mL 2.5337 mL 6.3342 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WR9921047326-86-3BRL 6231WR 99210WR-99210BRL6231BRL-6231Dihydrofolate reductase (DHFR)ParasiteP. falciparumparasitetoxoplasma gondiiT. gondiiInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
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目录号：
HY-116387
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