1,3,5-Trihydroxy-4-prenylxanthone  (Synonyms: 1,3,5-三羟基-4-异戊二烯氧蒽酮)

1,3,5-Trihydroxy-4-prenylxanthone is a Na⁺/H⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL^[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM^[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities^[2].

1,3,5-Trihydroxy-4-prenylxanthone（10-30 μM；18 小时）通过消除 IKK 磷酸化、IκB 降解和 NF-κB 核转位抑制 LPS 诱导的 iNOS 表达。 1,3,5-Trihydroxy-4-prenylxanthone 通过干扰 IRAK-1 的翻译后修饰来抑制 LPS 诱导的 iNOS 表达，从而阻断 TAK1 介导的 IKK 和 MAPK 信号转导激活，从而下调 NF-κB 和 AP-1 的激活^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

312.32

C₁₈H₁₆O₅

53377-61-0

1,3,5-三羟基-4-异戊二烯氧蒽酮

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. [1] M Kobayashi, et al. Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis. Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9.  [Content Brief]

  [2]. Wen-Fei Chiou, et al. 1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1. Biochem Pharmacol. 2011 Mar 15;81(6):752-60.  [Content Brief]

  [3]. Chalisa Sabphon, et al. Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis. Nat Prod Commun. 2015 Feb;10(2):301-3.  [Content Brief]