2. Cell Cycle/DNA Damage Apoptosis
  3. Nucleoside Antimetabolite/Analog Thymidylate Synthase
  4. FdUMP triethylammonium

FdUMP triethylammonium  (Synonyms: 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium)

目录号: HY-154508 纯度: 99.96%
COA 产品使用指南 技术支持

FdUMP (triethylammonium) 是 5-氟尿嘧啶 (5-FU) 的细胞内活性形式。5-FU 转运进入细胞后在多种酶的作用下转化为FdUMP。FdUMP 与胸苷酸合成酶 (thymidylate synthetase) 及其辅因子5,10-亚甲基四氢叶酸 (5,10-methylene tetrahydrofolate) 形成三元配合物抑制胸苷酸合成酶活性，进而导致 DNA 合成被抑制。

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FdUMP triethylammonium Chemical Structure

FdUMP triethylammonium Chemical Structure

CAS No. : 134-46-3

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规格 价格 是否有货 数量
1 mg ￥2000
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5 mg ￥4800
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FdUMP triethylammonium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
0.05 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
[PMID: 21892829]
CCRF-CEM IC50
1.06 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR
[PMID: 21892829]
CCRF-CEM IC50
1.74 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole
[PMID: 21892829]
CCRF-CEM IC50
3.6 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
[PMID: 21892829]
分子量

528.55

Formula

C21H42FN4O8P
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (236.50 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8920 mL 9.4598 mL 18.9197 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

FdUMP triethylammonium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8920 mL 9.4598 mL 18.9197 mL 47.2992 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL 9.4598 mL
10 mM 0.1892 mL 0.9460 mL 1.8920 mL 4.7299 mL
15 mM 0.1261 mL 0.6307 mL 1.2613 mL 3.1533 mL
20 mM 0.0946 mL 0.4730 mL 0.9460 mL 2.3650 mL
25 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8920 mL
30 mM 0.0631 mL 0.3153 mL 0.6307 mL 1.5766 mL
40 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1825 mL
50 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9460 mL
60 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7883 mL
80 mM 0.0236 mL 0.1182 mL 0.2365 mL 0.5912 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4730 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FdUMP134-46-32’-Deoxy-5-Fluorouridine 5’-phosphateNucleoside Antimetabolite/AnalogThymidylate Synthaseindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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