2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. (24S,25)-Epoxycholesterol

(24S,25)-Epoxycholesterol 

目录号: HY-W040150 纯度: 98.10%
COA 产品使用指南 技术支持

24S,25-Epoxycholesterol 是肝脏 X 受体 (LXR) 的激动剂。24S,25-Epoxycholesterol 具有调节胆固醇流出、抑制胃癌和胶质母细胞瘤肿瘤生长的特性并诱导 BMMC 细胞凋亡 (apoptosis)。

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(24S,25)-Epoxycholesterol Chemical Structure

(24S,25)-Epoxycholesterol Chemical Structure

CAS No. : 77058-74-3

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规格 价格 是否有货 数量
1 mg ￥4680
In-stock
5 mg   询价  
10 mg   询价  

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(24S,25)-Epoxycholesterol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

24S,25-Epoxycholesterol is an agonist for Liver X Receptor (LXR). 24S,25-Epoxycholesterol exhibits properties in regulating the cholesterol efflux[1], inhibiting tumor growth against gastric cancer and glioblastoma[2][3] and inducing apoptosis in BMMC cells[5].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CV-1 EC50
117 nM
Compound: 1
Agonist activity at human LXRalpha coexpressed in African green monkey CV1 cells by Gal4 responsive reporter gene assay
Agonist activity at human LXRalpha coexpressed in African green monkey CV1 cells by Gal4 responsive reporter gene assay
[PMID: 26990539]
CV-1 EC50
168 nM
Compound: 1
Agonist activity at human LXRbeta coexpressed in African green monkey CV1 cells by Gal4 responsive reporter gene assay
Agonist activity at human LXRbeta coexpressed in African green monkey CV1 cells by Gal4 responsive reporter gene assay
[PMID: 26990539]
SH-SY5Y EC50
0.4 μM
Compound: 1
Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay
Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay
[PMID: 19264481]
体外研究
(In Vitro)

24S,25-Epoxycholesterol (1-10 μM) 上调 LXR 相关基因 ABCA1、ABCG1 和 APOE，促进胆固醇流出，从而防止泡沫细胞形成，并通过消除细胞胆固醇来阻止小鼠和人类神经胶质瘤干细胞的增殖[1][3]。
24S,25-Epoxycholesterol 抑制 HGC27 的增殖和迁移，敲除 LXRβ 可增强这种增殖和迁移[2]。
24S,25-Epoxycholesterol (40 μM) 抑制 HMG-CoA 还原酶并激活 LXR，从而抑制甲羟戊酸 (mevalonate) 依赖性类异戊二烯 (isoprenoid) 的生成并增强 ATP 结合盒转运蛋白 G1 表达，诱导骨髓源性小鼠肥大细胞 (BMMC) 凋亡[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(24S,25)-Epoxycholesterol 相关抗体:

Cell Proliferation Assay[2]

Cell Line: HGC27
Concentration: 1 μM
Incubation Time: 18 h
Result: Inhibited proliferation of HGC27

Cell Migration Assay [2]

Cell Line: HGC27
Concentration: 1 μM
Incubation Time: 18 h
Result: Reduced HGC27 migration.
体内研究
(In Vivo)

24S,25-Epoxycholesterol (5 mM，脑室注射) 可增强 CYP46A1 过表达小鼠中脑的中脑多巴胺神经元 (mDA) 神经发生、限制神经变性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GGPP induced mDA neurogenesis defect in CYP46A1 overexpressing CD-1 mice[4]
Dosage: 5 mM
Administration: icv, 1 μL, single dosage
Result: Increased levels of mDA neurons, blocked the GGPP induced decrease of double EdU and TH cells.
分子量

400.64

Formula

C27H44O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : 16 mg/mL (39.94 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4960 mL 12.4800 mL 24.9601 mL
5 mM 0.4992 mL 2.4960 mL 4.9920 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.10%

COA (286 KB)

产品使用指南 (1538 KB)
参考文献

(24S,25)-Epoxycholesterol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.4960 mL 12.4800 mL 24.9601 mL 62.4002 mL
5 mM 0.4992 mL 2.4960 mL 4.9920 mL 12.4800 mL
10 mM 0.2496 mL 1.2480 mL 2.4960 mL 6.2400 mL
15 mM 0.1664 mL 0.8320 mL 1.6640 mL 4.1600 mL
20 mM 0.1248 mL 0.6240 mL 1.2480 mL 3.1200 mL
25 mM 0.0998 mL 0.4992 mL 0.9984 mL 2.4960 mL
30 mM 0.0832 mL 0.4160 mL 0.8320 mL 2.0800 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(24S,25)-Epoxycholesterol77058-74-3LXRLiver X receptorgastric cancerParkinson's diseaserheumatoid arthritismultiple sclerosistype I allergiesBMMCHGC27Inhibitorinhibitorinhibit

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