2. Cell Cycle/DNA Damage
  3. IRE1
  4. 3,6-DMAD hydrochloride

3,6-DMAD hydrochloride 

目录号: HY-U00460 纯度: 99.50%
COA 产品使用指南

摩尔计算器

3,6-DMAD hydrochloride 是一种吖啶衍生物，是一种有效的 IRE1α-XBP1s 通路抑制剂。 3,6-DMAD hydrochloride 通过 IRE1α-XBP1s 通路促进 IL-6 分泌。3,6-DMAD hydrochloride 可抑制 IRE1α 寡聚化和核糖核酸内切酶 (RNase) 活性。3,6-DMAD hydrochloride 可用于癌症的研究。

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3,6-DMAD hydrochloride Chemical Structure

3,6-DMAD hydrochloride Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1636
In-stock
5 mg ￥3600
In-stock
10 mg   询价  
50 mg   询价  

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Other Forms of 3,6-DMAD hydrochloride:

3,6-DMAD hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer[1][2].

体外研究
(In Vitro)

3,6-DMAD hydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines[1].
3,6-DMAD hydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner[1].
3,6-DMAD hydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity[1].
3,6-DMAD hydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3,6-DMAD hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: RPMI 8226 and MM1.R human MM cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 6 μM
Incubation Time: 24 hours
Result: Inhibited cell survival rate in a dose dependent manner.

Western Blot Analysis[1]

Cell Line: HT1080 cells treated with Tg (0.3 μM)
Concentration: 0, 5, 10 and 30 μM
Incubation Time: 14 hours
Result: Showed XBP1s inhibition at as low as 0.5 μM.
体内研究
(In Vivo)

3,6-DMAD hydrochloride (10 mg/kg; i.p.; three times every 12 hours, for 84 hours; NOD Scid mice with RPMI 8226 xenograft) has inhibition of XBP1 splicing in vivo[1].
3,6-DMAD hydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; three times every 12 hours, for 84 hours
Result: Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.
Animal Model: NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; every 48 hours, for 12 days
Result: Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.
Formula

C22H31N5
性状

固体

颜色

Yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.50%

COA (288 KB)

产品使用指南 (1538 KB)
参考文献

3,6-DMAD hydrochloride 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,6-DMADIRE1Inositol requiring enzyme 1RPMI 8226 cellIRE1α oligomerizationendoribonucleaseacridine derivativeanticancerInhibitorinhibitorinhibit

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