2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Oxidative Phosphorylation Amyloid-β
  4. 4-(6-Bromo-2-benzothiazolyl)benzenamine

4-(6-Bromo-2-benzothiazolyl)benzenamine 

目录号: HY-111514
COA 产品使用指南

摩尔计算器

4-(6-Bromo-2-benzothiazolyl)benzenamine是β-淀粉样蛋白 (β-amyloid) 的PET（正电子发射断层扫描）示踪剂，可用于诊断神经疾病，如阿尔茨海默病和唐氏综合征。

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4-(6-Bromo-2-benzothiazolyl)benzenamine Chemical Structure

4-(6-Bromo-2-benzothiazolyl)benzenamine Chemical Structure

CAS No. : 566169-97-9

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规格 价格 是否有货
5 mg ￥1440
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10 mg ￥2340
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4-(6-Bromo-2-benzothiazolyl)benzenamine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.

IC50 & Target

β-amyloid[1]
体外研究
(In Vitro)

4-(6-Bromo-2-benzothiazolyl)benzenamine (compound 6l) plus ultraviolet A (UVA) can induce caspase-3 activity, poly(ADP-ribose)polymerase cleavage, M30 positive CytoDeath staining, and subsequent apoptotic cell death. Treatment of A375 cells with 4-(6-Bromo-2-benzothiazolyl)benzenamine plus UVA results in a decrease in mitochondrial membrane potential (ΔΨmt), oxidative phosphorylation system (OXPHOS) subunits, and adenosine triphosphate (ATP) but an increase in mitochondrial DNA 4977-bp deletion via reactive oxygen species (ROS) generation. Transmission electron microscopy (TEM) observations also show major ultrastructural alterations of mitochondria[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-(6-Bromo-2-benzothiazolyl)benzenamine 相关抗体:
体内研究
(In Vivo)

4-(6-Bromo-2-benzothiazolyl)benzenamine plus UVA is shown to reduce murine melanoma size in a mouse model. 4-(6-Bromo-2-benzothiazolyl)benzenamine-PDT may serve as a potential ancillary modality for the treatment of melanoma[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

305.19

Formula

C13H9BrN2S
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

COA (260 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[2]

For fluorescence Measurement of Uptake of 4-(6-Bromo-2-benzothiazolyl)benzenamine, cultured A375 cells are seeded on glass coverslips with a density of 2×104 cells/well in 24-well plate for 24 h until cell attachment. Then the cells are exposed to 4-(6-Bromo-2-benzothiazolyl)benzenamine at 5 μM for indicated times in the dark. The cells are washed twice with PBS and are then fixed with 4% paraformaldehyde at 4°C for 30 min. The qualitative expression of cell fluorescence is determined using a Leica inverted microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Mice[2]

A total of 5×106 B16 cells are inoculated into female ICR mice (about 19-21 g, 7 weeks). The subcutaneous inoculation of tumor cells resulted in tumor generation at the injection site. When tumors reached about 4×4 mm2 in diameter, mice are separated into groups. Each group had four mice in each experiment; 4 mg/kg of 4-(6-Bromo-2-benzothiazolyl)benzenamine is injected into the tumor site, and then tumor is exposed to different doses of UVA on the day after injection. Tumor volume is measured by calipers every 5 days after agent injection, and tumor volume is calculated[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

4-(6-Bromo-2-benzothiazolyl)benzenamine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-(6-Bromo-2-benzothiazolyl)benzenamine566169-97-9Oxidative PhosphorylationAmyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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