2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. 4-Iodo-SAHA

4-Iodo-SAHA (1k) 是一种 I 类和 II 类 histone deacetylase (HDAC) 的抑制剂，对 Skbr3、HT29、U937、JA16 和 HL60 细胞的 EC50 值分别为 1.1、0.95、0.12、0.24、0.85 和 1.3 μM。4-Iodo-SAHA 可用于癌症的研究。

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4-Iodo-SAHA Chemical Structure

4-Iodo-SAHA Chemical Structure

CAS No. : 1219807-87-0

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规格 价格 是否有货 数量
50 mg ￥1881
3 - 4 周
100 mg   询价  
200 mg   询价  

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4-Iodo-SAHA 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC50s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 EC50
0.85 μM
Compound: 1k
Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
HT-29 EC50
0.95 μM
Compound: 1k
Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
Jurkat EC50
0.24 μM
Compound: 1k
Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
K562 EC50
1.3 μM
Compound: 1k
Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
SK-BR-3 EC50
1.1 μM
Compound: 1k
Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
U-937 EC50
0.12 μM
Compound: 1k
Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay
Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay
[PMID: 20218673]
体外研究
(In Vitro)

4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines [1].
4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-Iodo-SAHA 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SKBR3, HT29, U937, JA16 and HL60 cell lines
Concentration: 0.1-100 μM
Incubation Time: 48 h
Result: Inhibited SKBR3, HT29, U937, JA16 and HL60 cell lines with EC50s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM , respectively. Showed 10-fold potent as an inhibitor of U937 cell line compared to SAHA.

Western Blot Analysis[1]

Cell Line: SKBR3-breast-derived cell line
Concentration: 2 μM
Incubation Time: 6, 12 and 24 h
Result: Time-dependently up regulated histone H4 acetylation and p21/WAF1 cell cycle inhibitor accumulation in SKBR3 cells.
体内研究
(In Vivo)

4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old fvb mice[1]
Dosage: 50 mg/kg
Administration: Oral gavage; 50 mg/kg five times per week; for 2 weeks
Result: Compared to both SAHA-treated and control mice with similar body weights and hematological counts.
分子量

390.22

Formula

C14H19IN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Iodo-SAHA 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Iodo-SAHA1219807-87-0ISAHAHDACHistone deacetylasesoralantileukemiaSAHAantiproliferative activitycancerInhibitorinhibitorinhibit

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