2. Immunology/Inflammation NF-κB
  3. Complement System Toll-like Receptor (TLR) NF-κB
  4. 4-Octylphenol

4-Octylphenol 是一种激素干扰物，对男性生殖细胞具有性别特异性的影响, 使有丝分裂指数和前精原细胞数量显著降低。 4-Octylphenol 可引起鲤鱼鳃炎症损伤，通过启动补体成分 3a / 补体成分 3a 受体 (C3a/C3aR) 轴和补体成分 5a / 补体成分 5a 受体 1 (C5a/C5aR1) 轴引起补体 (Complement System) 激活，通过 T 辅助细胞 (Th) 1/Th2 细胞和调节性 T 细胞 (Treg) / Th17 细胞失衡引起免疫抑制，以及通过 Toll 样受体 7 (Toll-like Receptor (TLR)) / 抑制因子 κBα / 核因子 κB (TLR7/IκBα/NF-κB) 通路引起炎症损伤。

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4-Octylphenol Chemical Structure

4-Octylphenol Chemical Structure

CAS No. : 1806-26-4

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规格 价格 是否有货 数量
250 mg ￥154
1 - 2 周
1 g ￥394
1 - 2 周
5 g ￥1377
1 - 2 周
10 g   询价  
50 g   询价  

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Other Forms of 4-Octylphenol:

4-Octylphenol 相关抗体

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway[1][2].

分子量

206.32

Formula

C14H22O
CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献

4-Octylphenol 相关分类

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Keywords:

4-Octylphenol1806-26-4Complement SystemToll-like Receptor (TLR)NF-κBNuclear factor-κBNuclear factor-kappaBHormonesmitosismale germ cellsregulatory T cellsInhibitorinhibitorinhibit

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目录号：
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