2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. HDAC Virus Protease
  4. 4-Phenylbutyric acid-d2

4-Phenylbutyric acid-d2  (Synonyms: 4-PBA-d2; Benzenebutyric acid-d2)

目录号: HY-A0281S3
产品使用指南

摩尔计算器

4-Phenylbutyric acid-d2 是 4-Phenylbutyric acid 的氘代物。 4-Phenylbutyric acid (4-PBA) 是一种组蛋白去乙酰化酶 (HDAC) 和内质网应激 (ERS) 抑制剂，可用于癌症和感染等疾病的研究。

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4-Phenylbutyric acid-d<sub>2</sub> Chemical Structure

4-Phenylbutyric acid-d2 Chemical Structure

CAS No. : 461391-24-2

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Other Forms of 4-Phenylbutyric acid-d2:

4-Phenylbutyric acid-d2 相关抗体

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
8.94 mM
Compound: PBA
Antiproliferative activity against human A-375 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
[PMID: 35818137]
A549 IC50
9.75 mM
Compound: PBA
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
[PMID: 35818137]
LNCaP IC50
2324 μM
Compound: 4-PBA
Antiproliferative activity against human LNCAP cells after 24 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 24 hrs by MTT assay
[PMID: 21055848]
MCF7 IC50
10.68 mM
Compound: PBA
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
[PMID: 35818137]
MDA-MB-231 IC50
11.66 mM
Compound: PBA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
[PMID: 35818137]
PC-3 IC50
2273 μM
Compound: 4-PBA
Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay
[PMID: 21055848]
体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-Phenylbutyric acid-d2 相关抗体:
分子量

168.23

Formula

C10H8D4O2
CAS 号
非标记 CAS
中文名称

4-苯基丁酸-d2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Phenylbutyric acid-d2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Phenylbutyric acid-d2461391-24-24-PBA-d2Benzenebutyric acid-d24-苯基丁酸-d2HDACVirus ProteaseHistone deacetylasesInhibitorinhibitorinhibit

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