5-Aminolevulinic acid-¹⁵N hydrochloride  (Synonyms: 5-氨基乙酰丙酸-¹⁵N盐酸盐; 5-ALA-¹⁵N hydrochloride; δ-Aminolevulinic acid-¹⁵N hydrochloride; 5-Amino-4-oxopentanoic acid-¹⁵N hydrochloride)

5-Aminolevulinic acid-¹⁵N (hydrochloride) is the ¹⁵N-labeled 5-Aminolevulinic acid (hydrochloride). 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

168.58

C₅H₁₀Cl¹⁵NO₃

116571-80-3

5451-09-2

5-氨基乙酰丙酸-¹⁵N盐酸盐

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.  [Content Brief]

  [3]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.  [Content Brief]