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  4. (5aS,6R,6aR)-MK-8666

(5aS,6R,6aR)-MK-8666是一种选择性GPR40激动剂，具有促进胰腺β细胞和肠道肠内分泌细胞中脂肪酸诱导的胰岛素分泌的活性。(5aS,6R,6aR)-MK-8666被研究用于抑制2型糖尿病，表现出显著降低血糖的效果。虽然(5aS,6R,6aR)-MK-8666被认为具有潜在的抑制优势，但它在I期临床试验中因肝脏安全性问题而被停止开发。

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(5aS,6R,6aR)-MK-8666 Chemical Structure

(5aS,6R,6aR)-MK-8666 Chemical Structure

CAS No. : 1544739-76-5

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(5aS,6R,6aR)-MK-8666 相关抗体

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  • 生物活性

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生物活性

(5aS,6R,6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS,6R,6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR)-MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues[1].

分子量

521.62

Formula

C29H31NO6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(5aS,6R,6aR)-MK-8666 相关分类

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Keywords:

(5aS,6R,6aR)-MK-86661544739-76-5OthersInhibitorinhibitorinhibit

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