2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. 6-Deoxyjacareubin

6-Deoxyjacareubin 是一种天然氧杂蒽酮，可从 Vismia latifolia 的叶子中分离得到。 6-Deoxyjacareubin 通过抑制 ROS 产生来防止非凋亡性细胞死亡。 6-Deoxyjacareubin 可改善家族性肌萎缩侧索硬化症 (ALS) 小鼠模型的神经变性。

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6-Deoxyjacareubin Chemical Structure

6-Deoxyjacareubin Chemical Structure

CAS No. : 16265-56-8

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6-Deoxyjacareubin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].

体外研究
(In Vitro)

6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6-Deoxyjacareubin 相关抗体:
体内研究
(In Vivo)

6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SOD1G93A mice (eight weeks)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneally (i.p.), every seven days for 1 month
Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
分子量

310.30

Formula

C18H14O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6-Deoxyjacareubin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Deoxyjacareubin16265-56-8Reactive Oxygen SpeciesAmyotrophic lateral sclerosisHEK293T cellslocomotor dysfunctionnon-apoptotic cell deathHT1080MO3.13Neuro2aneurodegenerationInhibitorinhibitorinhibit

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