2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. 8-OAc

8-OAc 是一种强效且选择性的线粒体电子传递链 (ETC) 复合物 I (electron transport chain (ETC) complex I) 抑制剂。8-OAc 对癌细胞系表现出细胞毒性。

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8-OAc Chemical Structure

8-OAc Chemical Structure

CAS No. : 2550395-87-2

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8-OAc 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines[1].

体外研究
(In Vitro)

8-OAc (5-100 μM；24 小时) 可以优先靶向癌细胞以启动细胞死亡途径，同时对非癌细胞的生存力影响最小。8-OAc 可诱导 ROS 生成，导致肝癌细胞死亡[1]。
8-OAc 能够在秀丽隐杆线虫中产生线粒体兴奋效应，并延长成虫寿命。8-OAc 需要 HSF1 介导热休克反应 (HSR) 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-OAc 相关抗体:

Cell Viability Assay[1]

Cell Line: Huh-7 liver carcinoma cells and BJ fibroblast non-cancer cells
Concentration: 5 μM, 10 μM, 50 μM, 100 μM
Incubation Time: 24 h
Result: Inhibited Huh-7 and BJ cells with IC50 of 95.97 μM and 248.15 μM, respectively.
分子量

446.60

Formula

C24H34N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8-OAc 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-OAc2550395-87-2Mitochondrial Metabolismmitochondrial functionagingETC complex IHSF1Inhibitorinhibitorinhibit

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目录号：
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