2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease NF-κB Immunology/Inflammation JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. PPAR Reactive Oxygen Species STAT NF-κB Apoptosis
  4. Astaxanthin

Astaxanthin  (Synonyms: 虾青素)

目录号: HY-B2163 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Astaxanthin，红色膳食类胡萝卜素，是一种口服有效的强效抗氧化剂。Astaxanthin 可抑制 NF-κB，能在蛋白质水平下调高血糖中的 VEGF。Astaxanthin 通过激活 PPARγ 并减少 STAT3 和相关通路蛋白的表达，发挥抗癌细胞增殖、增加凋亡以及削弱迁移和侵袭的活性。Astaxanthin 还具有神经保护和抗炎活性可用于癌症，糖尿病视网膜病变，心血管疾病等研究以及动物饲料的着色。

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Astaxanthin Chemical Structure

Astaxanthin Chemical Structure

CAS No. : 472-61-7

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10 mg ￥700
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Customer Review

Other Forms of Astaxanthin:

Astaxanthin 相关抗体

Top Publications Citing Use of Products

    Astaxanthin purchased from MCE. Usage Cited in: Exp Biol Med. 2023 Jan 23;15353702221147568.  [Abstract]

    Astaxanthin (ASTA) decreases levels of caspase 3 and caspase 9 in MLE-12 cells, which reveals that ASTA prevents apoptosis stimulated by LPS in MLE-12 cells.

    Astaxanthin purchased from MCE. Usage Cited in: Exp Biol Med. 2023 Jan 23;15353702221147568.  [Abstract]

    Astaxanthin (ASTA) inhibits apoptosis by targeting NF-κB signal pathway in MLE-12 cells.

    查看 PPAR 亚型特异性产品:

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    PPARα PPARβ/δ PPARγ PPAR PPARδ

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    STAT3 STAT5 STAT6 STAT1

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].

    IC50 & Target[1][2][3][4]

    PPARγ

     

    STAT3

     

    体外研究
    (In Vitro)

    Astaxanthin (50、100、150、200 μM；48 小时) 抑制 DU145 细胞增殖 (IC50 值 <200 μM)[1]。
    Astaxanthin (200 μM；24 小时) 通过抑制增殖、增加细胞凋亡和削弱迁移和侵袭来降低 STAT3 和相关通路蛋白的表达（在蛋白质和 mRNA 水平上）[1]
    虾青素通过在高糖下在蛋白质水平上下调 VEGF 来保护 RPE 细胞免受异常活化和氧化应激（高糖诱导）[2]。
    Astaxanthin (1-50 μM；72 小时) 以时间和剂量依赖性方式上调 K562 细胞中 PPARγ 的蛋白质表达[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Astaxanthin 相关抗体:

    Apoptosis Analysis[1]

    Cell Line: DU145 cells
    Concentration: 200 µM (pre-incubation)
    Incubation Time: 24 h
    Result: Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control).

    Cell Migration Assay [1]

    Cell Line: DU145 cells
    Concentration: 200 µM
    Incubation Time: 24 h
    Result: Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group).

    Cell Proliferation Assay[2]

    Cell Line: ARPE-19 cells
    Concentration: 50 µM (pre-incubation)
    Incubation Time: 7 days
    Result: Significantly decreased cell proliferation exposed to high glucose.

    Western Blot Analysis[1]

    Cell Line: DU145 cells
    Concentration: 200 µM
    Incubation Time: 24 h
    Result: Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9).

    Western Blot Analysis[3]

    Cell Line: K562 cells
    Concentration: 1-50 µM
    Incubation Time: 72 h
    Result: Significantly promoted PPARγ protein expression in time- and dose-dependent manners.
    体内研究
    (In Vivo)

    Astaxanthin（200 mg/kg；胃内给药；每天一次，持续 3 周）可抑制裸鼠 DU145 肿瘤异种移植瘤的生长[1]。
    Astaxanthin（125 或 500 mg/kg；动物喂养；7 天）可为大鼠提供显著的心脏保护作用，并降低氧化应激[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nude mice (approximately 20 g; DU145 tumor xenografts model)[1].
    Dosage: 200 mg/kg
    Administration: Intragastric administration; once daily for 3 weeks.
    Result: Exerted a significant inhibitory effect on tumor growth.
    Animal Model: Female C57BL/6 mice (7 weeks old)[4].
    Dosage: 125 or 500 mg/kg
    Administration: In animal feedings; 7 days.
    Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.
    Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively.
    Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
    Clinical Trial
    分子量

    596.84

    Formula

    C40H52O4
    CAS 号
    性状

    固体

    颜色

    Dark purple to black

    中文名称

    虾青素
    结构分类
    初始来源

    Haematococcus pluvialis
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    -20°C, protect from light, stored under nitrogen

    *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 2 mg/mL (3.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    Acetone 中的溶解度 : < 1 mg/mL (insoluble)

    *Astaxanthin is usually formulated as a suspension.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.6755 mL 8.3775 mL 16.7549 mL
    5 mM --- --- ---
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： 0.5% CMC-Na/saline water

      Solubility: 3.33 mg/mL (5.58 mM); 悬浊液; 超声加热助溶

    • 方案 二

      请依序添加每种溶剂： 20% HP-β-CD in Saline

      Solubility: 3.33 mg/mL (5.58 mM); 悬浊液; 超声加热助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (189 KB) HNMR (290 KB)

    产品使用指南 (1538 KB)
    参考文献

    Astaxanthin 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6755 mL 8.3775 mL 16.7549 mL 41.8873 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Astaxanthin472-61-7虾青素PPARReactive Oxygen SpeciesSTATNF-κBApoptosisPeroxisome proliferator-activated receptorsNuclear factor-κBNuclear factor-kappaBDU145cancerSTAT3DRROSapoptosisARPE-19K562Inhibitorinhibitorinhibit

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    目录号：
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