2. Metabolic Enzyme/Protease Apoptosis Autophagy
  3. Phosphatase Apoptosis Autophagy
  4. CCT007093

CCT007093 是有效的蛋白磷酸酶 1D (PPM1D Wip1) 的抑制剂。Wip1 的抑制可激活mTORC1 通路，增强肝切除手术后肝细胞的增殖。

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CCT007093 Chemical Structure

CCT007093 Chemical Structure

CAS No. : 176957-55-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥440
In-stock
5 mg ￥400
In-stock
10 mg ￥660
In-stock
50 mg ￥2350
In-stock
100 mg ￥3800
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

CCT007093 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy[1][2].

体外研究
(In Vitro)

CCT007093 (25 or 50 µM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line[1].
CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells[2].
CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CCT007093 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cell line.
Concentration: 25 or 50 µM.
Incubation Time: 8 h.
Result: The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased[1].
The phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) were also up-regulated[1].
体内研究
(In Vivo)

CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type mice[1].
Dosage: 3.2 and 6.4 mg/kg.
Administration: Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH).
Result: Significantly improved survival in mice following major hepatectomy (80% hepatectomy).
The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.
分子量

272.39

Formula

C15H12OS2
CAS 号
性状

固体

颜色

Light green to green

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMF 中的溶解度 : 3.33 mg/mL (12.23 mM; 超声助溶)

DMSO 中的溶解度 : ≥ 2.8 mg/mL (10.28 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6712 mL 18.3560 mL 36.7121 mL
5 mM 0.7342 mL 3.6712 mL 7.3424 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.01%

COA (286 KB) HNMR (245 KB) LCMS (258 KB)

产品使用指南 (1538 KB)
参考文献

CCT007093 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 3.6712 mL 18.3560 mL 36.7121 mL 91.7802 mL
5 mM 0.7342 mL 3.6712 mL 7.3424 mL 18.3560 mL
10 mM 0.3671 mL 1.8356 mL 3.6712 mL 9.1780 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT007093176957-55-4CCT 007093CCT-007093PhosphataseApoptosisAutophagyInhibitorinhibitorinhibit

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目录号：
HY-15880
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