2. Anti-infection
  3. Bacterial Antibiotic
  4. Clinafloxacin

Clinafloxacin  (Synonyms: 克林沙星; AM-1091; CI-960; PD 127391)

目录号: HY-B0536 纯度: 98.34%
COA 产品使用指南

摩尔计算器

Clinafloxacin (AM 1091) 是一种高效广谱氟喹诺酮类抗生素 (antibiotic)，对革兰氏阳性、革兰氏阴性和厌氧病原体均有抑制活性。Clinafloxacin 对金黄色葡萄球菌的 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 有抑制作用，IC50 值分别为 0.92 μg/ml 和 1.62 μg/ml。

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Clinafloxacin Chemical Structure

Clinafloxacin Chemical Structure

CAS No. : 105956-97-6

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规格 价格 是否有货 数量
5 mg ￥245
In-stock
10 mg ￥385
In-stock
25 mg ￥665
In-stock
50 mg ￥980
In-stock
100 mg ￥1470
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Clinafloxacin:

Clinafloxacin 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro[1]. Clinafloxacin is against DNA gyrase and topoisomerase IV of?S. aureus with IC50 values of 0.92 μg/ml and 1.62 μg/ml, respectively[2].

IC50 & Target

Quinolone

 

体外研究
(In Vitro)

Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[2].
Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of?S. aureus. It against Wild type S. aureus, gyrA?mutant S. aureus and gyrA?mutant S. aureus with MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinafloxacin 相关抗体:
体内研究
(In Vivo)

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.79

Formula

C17H17ClFN3O3
CAS 号
性状

固体

颜色

Light yellow to brown

中文名称

克林沙星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (273.38 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7338 mL 13.6690 mL 27.3381 mL
5 mM 0.5468 mL 2.7338 mL 5.4676 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.34%

COA (286 KB) HNMR (209 KB) RP-HPLC (204 KB) LCMS (107 KB)

产品使用指南 (1538 KB)
参考文献

Clinafloxacin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7338 mL 13.6690 mL 27.3381 mL 68.3452 mL
5 mM 0.5468 mL 2.7338 mL 5.4676 mL 13.6690 mL
10 mM 0.2734 mL 1.3669 mL 2.7338 mL 6.8345 mL
15 mM 0.1823 mL 0.9113 mL 1.8225 mL 4.5563 mL
20 mM 0.1367 mL 0.6835 mL 1.3669 mL 3.4173 mL
25 mM 0.1094 mL 0.5468 mL 1.0935 mL 2.7338 mL
30 mM 0.0911 mL 0.4556 mL 0.9113 mL 2.2782 mL
40 mM 0.0683 mL 0.3417 mL 0.6835 mL 1.7086 mL
50 mM 0.0547 mL 0.2734 mL 0.5468 mL 1.3669 mL
60 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1391 mL
80 mM 0.0342 mL 0.1709 mL 0.3417 mL 0.8543 mL
100 mM 0.0273 mL 0.1367 mL 0.2734 mL 0.6835 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clinafloxacin105956-97-6AM-1091 CI-960 PD 127391克林沙星AM1091AM 1091CI960CI 960CI-960PD127391PD 127391PD-127391BacterialAntibioticanaerobic pathogenantibioticbacteriaS. aureuspneumococcal meningitisInhibitorinhibitorinhibit

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