Heparan Sulfate (Synonyms: 硫酸乙酰肝素)

目录号: HY-101916: FAQs
Data Sheet SDS COA 产品使用指南技术支持

Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白聚糖的一部分出现，在细胞表面和细胞外基质中表达丰富。

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Heparan Sulfate Chemical Structure

CAS No. : 9050-30-0

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Heparan sulfate 是一种线性多糖，属于糖胺聚糖家族。硫酸肝素由葡萄糖醛酸 (GlcA) 和艾杜糖醛酸 (IdoA) 残基以及具有各种硫酸化修饰的 N-乙酰葡萄糖胺 (GlcNAc) 组成，长度通常为 50-200 个二糖。Heparan sulfate 与多种蛋白质相互作用，包括生长因子、形态发生素和粘附分子，从而调节无脊椎动物和脊椎动物的重要发育过程。Heparan sulfate 链通过多种机制作为辅助因子来调节发育信号，这些机制包括但不限于维持形态发生素梯度和辅助受体功能^[1]。
Heparan sulfate 蛋白聚糖可作为蛋白酶和蛋白酶抑制剂的受体，调节其空间分布和活性。膜 Heparan sulfate 蛋白聚糖作为各种酪氨酸激酶型生长因子受体的辅助受体，降低其激活阈值或改变信号反应的持续时间^[2]。
Heparan sulfate 影响肠上皮细胞与 Wnt 的结合亲和力，从而促进经典 Wnt 信号的激活，促进上皮损伤后小肠隐窝的再生^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Heparan sulfate 的消化会损害恐惧条件反射范式中的背景辨别能力和恐惧条件反射后的低频 θ 波段振荡网络活动。因此，Heparan sulfate 可维持神经元的兴奋性，从而支持突触可塑性和学习^[4]。
FGF-2/FGFR 系统参与调节大脑中的星形胶质细胞反应性和/或增殖，其作用因 Heparan sulfate 而增强^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

593.47 (monomer)

Formula

C₁₂H₁₉NO₂₀S₃ (monomer)

CAS 号

9050-30-0

性状

固体

颜色

White to off-white

中文名称

硫酸乙酰肝素

结构分类

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

细胞实验：

H₂O 中的溶解度 : 100 mg/mL (超声助溶)

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL; 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

选择批次：

Data Sheet (653 KB) SDS (393 KB)

COA (273 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Kraushaar DC, et al. Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem. 2013 Jun;394(6):741-51. [Content Brief]

[2]. Sarrazin S, et al. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a004952. [Content Brief]

[3]. Yamamoto S, et al. Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G241-9. [Content Brief]

[4]. Minge D, et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex. 2017 Feb 1;27(2):903-918. [Content Brief]

[5]. Gómez-Pinilla F, et al. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar;15(3 Pt 1):2021-9. [Content Brief]

Animal Administration ^[5]	Rats: Sprague-Dawley male rats 3-4 months old receive aspiration of a small segment of the motor-sensory cortex in both hemispheres. Groups of rats (n=5) receive a piece of Gelfoam embedded with human recombinant FGF-2, heparan sulfate (10 kg/mL; sodium salt, bovine kidney) dissolved in PBS, or both, in the right hemisphere. The wound cavity of the left hemisphere receives a piece of Gelfoam embedded with saline^[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Kraushaar DC, et al. Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem. 2013 Jun;394(6):741-51. [Content Brief] [2]. Sarrazin S, et al. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a004952. [Content Brief] [3]. Yamamoto S, et al. Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G241-9. [Content Brief] [4]. Minge D, et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex. 2017 Feb 1;27(2):903-918. [Content Brief] [5]. Gómez-Pinilla F, et al. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar;15(3 Pt 1):2021-9. [Content Brief]

Animal Administration
^[5]

Rats: Sprague-Dawley male rats 3-4 months old receive aspiration of a small segment of the motor-sensory cortex in both hemispheres. Groups of rats (n=5) receive a piece of Gelfoam embedded with human recombinant FGF-2, heparan sulfate (10 kg/mL; sodium salt, bovine kidney) dissolved in PBS, or both, in the right hemisphere. The wound cavity of the left hemisphere receives a piece of Gelfoam embedded with saline^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Kraushaar DC, et al. Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem. 2013 Jun;394(6):741-51. [Content Brief]

[2]. Sarrazin S, et al. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a004952. [Content Brief]

[3]. Yamamoto S, et al. Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G241-9. [Content Brief]

[4]. Minge D, et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex. 2017 Feb 1;27(2):903-918. [Content Brief]

[5]. Gómez-Pinilla F, et al. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar;15(3 Pt 1):2021-9. [Content Brief]

Heparan Sulfate 相关分类

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Heparan9050-30-0硫酸乙酰肝素FGFRWntEndogenous MetaboliteFibroblast growth factor receptorInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Heparan Sulfate (Synonyms: 硫酸乙酰肝素)

Customer Review

MCE 顾客使用本产品发表的 14 篇科研文献