2. Apoptosis Autophagy
  3. c-Myc Autophagy
  4. IZCZ-3

IZCZ-3 是有效的 c-MYC 转录抑制剂，具有抗肿瘤活性。

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IZCZ-3 Chemical Structure

IZCZ-3 Chemical Structure

CAS No. : 2223019-53-0

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IZCZ-3 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

WB

    IZCZ-3 purchased from MCE. Usage Cited in: Oncogene. 2022 Oct 21.  [Abstract]

    IZCZ-3 (0.5 μM; 24 h) co-operates with IFNγ to induce differentiation in NB4 cells.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity[1].

    IC50 & Target

    c-MYC transcription[1]
    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A-375 IC50
    4.2 μM
    Compound: IZCZ-3
    Cytotoxicity against human A375 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human A375 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29474069]
    BJ IC50
    15.9 μM
    Compound: IZCZ-3
    Cytotoxicity against human BJ cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human BJ cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29474069]
    HBL-100 IC50
    11.2 μM
    Compound: 1; IZCZ-3
    Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 36121464]
    HeLa IC50
    2.1 μM
    Compound: IZCZ-3
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29474069]
    HepG2 IC50
    6.1 μM
    Compound: 1; IZCZ-3
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 36121464]
    Huh-7 IC50
    4.1 μM
    Compound: IZCZ-3
    Cytotoxicity against human Huh7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human Huh7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29474069]
    MDA-MB-231 IC50
    5.1 μM
    Compound: 1; IZCZ-3
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 36121464]
    SiHa IC50
    3.3 μM
    Compound: IZCZ-3
    Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29474069]
    U2OS IC50
    6.8 μM
    Compound: IZCZ-3
    Cytotoxicity against human U2OS cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human U2OS cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 29474069]
    体外研究
    (In Vitro)

    IZCZ-3 (2.1 μM-15.9 μM；24 小时) 显著抑制 SiHa、HeLa、Huh7 和 A375 癌细胞增殖 (IC50 分别为 3.3、2.1，4.1 和 4.2 μM) . IZCZ-3 在 BJ 成纤维细胞 (IC50=15.9 μM) 和小鼠系膜细胞 (IC50=15.6 μM) 中仅诱导微弱的生长抑制，表明 IZCZ-3 对癌细胞比对不依赖 c-MYC 的正常细胞更有效[1]。
    IZCZ-3 (0-5 μM；12 hours) 以剂量依赖性方式诱导 SiHa 细胞 G0/G1 期细胞明显积累[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    IZCZ-3 相关抗体:

    Cell Proliferation Assay[1]

    Cell Line: SiHa, HeLa, Huh7, and A375 cancer cells (with overexpression of c-MYC protein) and in normal BJ fibroblasts and primary cultured mouse mesangial cells (with relatively low expression of c-MYC protein).
    Concentration: 2.1 μM-15.9 μM
    Incubation Time: 24 hours
    Result: IC50s of 3.3, 2.1，4.1, and 4.2 μM for SiHa, HeLa, Huh7, and A375 cancer cells; IC50s of 15.9 μM and 15.6 μM for BJ fibroblasts and mouse mesangial cells.

    Cell Cycle Analysis[1]

    Cell Line: SiHa cells
    Concentration: 0, 1.25, 2.5, and 5 μM
    Incubation Time: 12 hours
    Result: Induced an apparent accumulation of cells in the G0/G1 phase (increasing from 61% to 70%) in a dose-dependent manner.
    体内研究
    (In Vivo)

    IZCZ-3 (20、10 和 5 mg/kg；腹膜内给药；每隔一天给药一次，持续 24 天) 抑制带有 SiHa 人宫颈鳞癌异种移植物的 BALB/c 裸鼠的肿瘤生长[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c nude mice (5 weeks old) bearing SiHa human cervical squamous cancer xenograft model[1]
    Dosage: 20, 10, and 5 mg/kg
    Administration: Treated intraperitoneally; every other day for 24 days
    Result: Treatment with 20, 10, and 5 mg/kg resulted in a significant reduction in tumor weight with tumor growth inhibition (TGI) of 69%, 64%, and 57%, respectively. Displayed time-dependent inhibition of tumor growth.
    分子量

    715.93

    Formula

    C46H49N7O
    CAS 号
    性状

    固体

    颜色

    Off-white to pink

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 5 mg/mL (6.98 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.3968 mL 6.9839 mL 13.9678 mL
    5 mM 0.2794 mL 1.3968 mL 2.7936 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    IZCZ-3 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.3968 mL 6.9839 mL 13.9678 mL 34.9196 mL
    5 mM 0.2794 mL 1.3968 mL 2.7936 mL 6.9839 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    IZCZ-32223019-53-0IZCZ3IZCZ 3c-MycAutophagyMycInhibitorinhibitorinhibit

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    目录号：
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