2. JAK/STAT Signaling Stem Cell/Wnt Anti-infection
  3. STAT Antibiotic Parasite
  4. Niclosamide monohydrate

Niclosamide monohydrate  (Synonyms: 氯硝柳胺一水合物; BAY2353 monohydrate)

目录号: HY-B0497B
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摩尔计算器

Niclosamide (BAY2353) monohydrate 是一种具有口服活性的用于寄生虫感染研究的抗蠕虫化合物。Niclosamide monohydrate 是 STAT3 抑制剂，在 HeLa 细胞中的 IC50 为 0.25 μM。Niclosamide monohydrate 具有抗癌的生物活性，并能抑制 Vero E6 细胞的 DNA 复制。

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Niclosamide monohydrate Chemical Structure

Niclosamide monohydrate Chemical Structure

CAS No. : 73360-56-2

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Niclosamide monohydrate 的其他形式现货产品:

Other Forms of Niclosamide monohydrate:

Niclosamide monohydrate 相关抗体

Top Publications Citing Use of Products

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC) significantly suppresses the colony formation ability, and reduces the numbers, as well as diameters, of colonies formed in AN3CA, Hec1B, and Ishikawa cells.

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 1 μM) reduces number of cells that invaded across the trans-well chamber in Hec1B and Ishikawa endometrial cancer cell lines, suggesting NIC-mediated inhibition of invasive property of endometrial cancer cells.

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 0-8 μM; 24, 48, 72 h) significantly inhibits the metabolic viability of AN3CA, Hec1B, and Ishikawa cells both in a dose-dependent and a time-dependent manner, with the half maximal inhibitory concentration of < 1 μM at 72 h.

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 5 μM; 24 h) significantly reduces cyclin D1 and vimentin protein expression in human endometrial cancer cells.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

    IC50 & Target[1]

    STAT3

    0.25 μM (IC50, in HeLa cells)

    体外研究
    (In Vitro)

    Niclosamide monohydrate (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].
    Niclosamide monohydrate (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells [4].
    Niclosamide monohydrate (10 μM) treatment inhibits virus replication in Vero E6 cells[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Niclosamide monohydrate 相关抗体:

    Cell Viability Assay[3]

    Cell Line: BD140A, SW-13 and NCI-H295R cells
    Concentration: 0.6 nM-46 µM
    Incubation Time:
    Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 µM, 0.15 µM, and 0.53 µM in BD140A, SW-13, and NCI-H295R, respectively.

    Cell Viability Assay[4]

    Cell Line: Hela cells
    Concentration: 0.05-5 μM
    Incubation Time: 24 hours
    Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.

    Cell Viability Assay[5]

    Cell Line: Vero E6 cells
    Concentration: 10 μM
    Incubation Time: 2 days
    Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
    体内研究
    (In Vivo)

    Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nu+/Nu+ mice injected with NCI-H295R cells[3]
    Dosage: 100 mg/kg, 200 mg/kg
    Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
    Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
    Clinical Trial
    分子量

    345.13

    Formula

    C13H10Cl2N2O5
    CAS 号
    中文名称

    氯硝柳胺一水合物
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Niclosamide monohydrate 相关分类

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    • Do most proteins show cross-species activity?

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    Keywords:

    Niclosamide73360-56-2BAY2353氯硝柳胺一水合物BAY 2353BAY-2353STATAntibioticParasiteBD140ASW-13NCI-H295RHelaVero E6antihelminthicbayluscideInhibitorinhibitorinhibit

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