Niclosamide  (Synonyms: BAY2353)

Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research^[1]. Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells^[4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells^[2][3][5].

Niclosamide (0.6 nM-46 μM) 处理可抑制 BD140A、SW-13 和 NCI-H295R 细胞中的肾上腺皮质癌细胞增殖^[3]。
Niclosamide (0.05-5 μM，24 h) 处理抑制 HeLa 细胞中 STAT3 介导的荧光素酶报告基因活性^[4]。
Niclosamide (10 μM) 处理抑制 Vero E6 细胞中的病毒复制^[5]。
Niclosamide (GMP) (最大至 2 μM, 24 h) 对SNB-19 细胞的寨卡病毒感染有抑制作用^[6]。
Niclosamide (GMP) (1.5 μM, 5 d) 抑制 factor‐κB 配体 (RANKL) 诱导的巨噬细胞向前体破骨细胞体转分化 (特别是在破骨细胞发生的早期) ^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Niclosamide (口服灌胃；100 mg/kg、200 mg/kg；每周一次；8 周) 处理抑制体内肾上腺皮质癌肿瘤生长^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

327.12

C₁₃H₈Cl₂N₂O₄

50-65-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19(2):245-95.  [Content Brief]

  [2]. Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.  [Content Brief]

  [3]. Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22(14):3458-66.  [Content Brief]

  [4]. Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9.  [Content Brief]

  [5]. Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6.  [Content Brief]

  [6]. Xu M, Lee EM, Wen Z, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016;22(10):1101-1107.  [Content Brief]

  [7]. Jiao Y, Chen C, Hu X, et al. Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis. FEBS Open Bio. 2020;10(8):1685-1697. doi:10.1002/2211-5463.12921  [Content Brief]