2. JAK/STAT Signaling Stem Cell/Wnt Anti-infection
  3. STAT Parasite Antibiotic
  4. Niclosamide olamine

Niclosamide olamine  (Synonyms: BAY2353 olamine)

目录号: HY-B0497C 纯度: 99.44%
COA 产品使用指南

摩尔计算器

Niclosamide (BAY2353) olamine 是一种具有口服活性的用于寄生虫感染研究的抗蠕虫化合物。Niclosamide olamine 是 STAT3 抑制剂，在 HeLa 细胞中的 IC50 为 0.25 μM。Niclosamide olamine 具有抗癌的生物活性，并能抑制 Vero E6 细胞的 DNA 复制。

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Niclosamide olamine Chemical Structure

Niclosamide olamine Chemical Structure

CAS No. : 1420-04-8

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Customer Review

Other Forms of Niclosamide olamine:

Niclosamide olamine 相关抗体

Top Publications Citing Use of Products

    Niclosamide olamine purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC) significantly suppresses the colony formation ability, and reduces the numbers, as well as diameters, of colonies formed in AN3CA, Hec1B, and Ishikawa cells.

    Niclosamide olamine purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 1 μM) reduces number of cells that invaded across the trans-well chamber in Hec1B and Ishikawa endometrial cancer cell lines, suggesting NIC-mediated inhibition of invasive property of endometrial cancer cells.

    Niclosamide olamine purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 0-8 μM; 24, 48, 72 h) significantly inhibits the metabolic viability of AN3CA, Hec1B, and Ishikawa cells both in a dose-dependent and a time-dependent manner, with the half maximal inhibitory concentration of < 1 μM at 72 h.

    Niclosamide olamine purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 5 μM; 24 h) significantly reduces cyclin D1 and vimentin protein expression in human endometrial cancer cells.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

    体外研究
    (In Vitro)

    氯硝柳胺 (0.6 nM-46 μ M) 处理可抑制 BD140A、SW-13 和 NCI-H295R 细胞的肾上腺皮质癌细胞增殖[3]。
    氯硝柳胺 (0.05-5 μM, 24 h) 处理抑制 STAT3 介导的 HeLa 细胞荧光素酶报告活性[4]。
    氯硝柳胺 (10 μM) 处理抑制病毒在 Vero E6 细胞中的复制[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Niclosamide olamine 相关抗体:

    Cell Viability Assay[3]

    Cell Line: BD140A, SW-13 and NCI-H295R cells
    Concentration: 0.6 nM-46 µM
    Incubation Time:
    Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 µM, 0.15 µM, and 0.53 µM in BD140A, SW-13, and NCI-H295R, respectively.

    Cell Viability Assay[4]

    Cell Line: Hela cells
    Concentration: 0.05-5 μM
    Incubation Time: 24 hours
    Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.

    Cell Viability Assay[5]

    Cell Line: Vero E6 cells
    Concentration: 10 μM
    Incubation Time: 2 days
    Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
    体内研究
    (In Vivo)

    氯硝柳胺钠 (灌胃; 100 mg/kg, 200 mg/kg;一周一次; 8周) 处理抑制肾上腺皮质癌肿瘤在体内生长[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nu+/Nu+ mice injected with NCI-H295R cells[3]
    Dosage: 100 mg/kg, 200 mg/kg
    Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
    Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
    Clinical Trial
    分子量

    388.20

    Formula

    C15H15Cl2N3O5
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 125 mg/mL (322.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5760 mL 12.8800 mL 25.7599 mL
    5 mM 0.5152 mL 2.5760 mL 5.1520 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Niclosamide olamine 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.5760 mL 12.8800 mL 25.7599 mL 64.3998 mL
    5 mM 0.5152 mL 2.5760 mL 5.1520 mL 12.8800 mL
    10 mM 0.2576 mL 1.2880 mL 2.5760 mL 6.4400 mL
    15 mM 0.1717 mL 0.8587 mL 1.7173 mL 4.2933 mL
    20 mM 0.1288 mL 0.6440 mL 1.2880 mL 3.2200 mL
    25 mM 0.1030 mL 0.5152 mL 1.0304 mL 2.5760 mL
    30 mM 0.0859 mL 0.4293 mL 0.8587 mL 2.1467 mL
    40 mM 0.0644 mL 0.3220 mL 0.6440 mL 1.6100 mL
    50 mM 0.0515 mL 0.2576 mL 0.5152 mL 1.2880 mL
    60 mM 0.0429 mL 0.2147 mL 0.4293 mL 1.0733 mL
    80 mM 0.0322 mL 0.1610 mL 0.3220 mL 0.8050 mL
    100 mM 0.0258 mL 0.1288 mL 0.2576 mL 0.6440 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Niclosamide1420-04-8BAY2353BAY 2353BAY-2353STATParasiteAntibioticInhibitorinhibitorinhibit

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