1. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  2. PI3K Bcr-Abl
  3. ON 146040

ON 146040 是一种有效的 PI3KαPI3Kδ 抑制剂,IC50 分别约为 14 和 20 nM。ON 146040 也抑制 Abl1 (IC50<150 nM)。

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ON 146040 Chemical Structure

ON 146040 Chemical Structure

CAS No. : 1404231-34-0

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3231
In-stock
1 mg ¥1200
In-stock
5 mg ¥3000
In-stock
10 mg ¥4800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).

IC50 & Target[1]

PI3Kα

14 nM (IC50)

PI3Kδ

20 nM (IC50)

PI3Kγ

1 μM (IC50)

PI3Kβ

3 μM (IC50)

体外研究
(In Vitro)

In biochemical testing, ON 146040 inhibits PI3Kα/ PI3Kδ isoforms (IC50≈14 and 20 nM, respectively) without having a major effect on PI3Kβ/ PI3Kγ isoforms (IC50≈3 and 1 μM, respectively). ON 146040 is also found to inhibit Abl1 and several mutant versions of this kinase (IC50<150 nM), although ON 146040 is not found to be active against the T315I mutant. ON 146040 represents the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways. ON 146040 disrupts the oncogenic activity of both STAT3 and STAT5 by targeting upstream activators, including PI3K α and δ isoforms as well as wild type and mutant BCR-ABL. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation are down-regulated in leukemia and myeloma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

489.55

Formula

C24H23N7O3S

CAS 号
性状

固体

颜色

Brown to reddish brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 25 mg/mL (51.07 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0427 mL 10.2135 mL 20.4269 mL
5 mM 0.4085 mL 2.0427 mL 4.0854 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0427 mL 10.2135 mL 20.4269 mL 51.0673 mL
5 mM 0.4085 mL 2.0427 mL 4.0854 mL 10.2135 mL
10 mM 0.2043 mL 1.0213 mL 2.0427 mL 5.1067 mL
15 mM 0.1362 mL 0.6809 mL 1.3618 mL 3.4045 mL
20 mM 0.1021 mL 0.5107 mL 1.0213 mL 2.5534 mL
25 mM 0.0817 mL 0.4085 mL 0.8171 mL 2.0427 mL
30 mM 0.0681 mL 0.3404 mL 0.6809 mL 1.7022 mL
40 mM 0.0511 mL 0.2553 mL 0.5107 mL 1.2767 mL
50 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
ON 146040
目录号:
HY-12338
需求量: