786-0
|
GI50 |
0.513 μM
Compound: PU-H71
|
Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
A498
|
GI50 |
0.437 μM
Compound: PU-H71
|
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
A549
|
GI50 |
0.087 μM
Compound: PU-H71
|
Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
ACHN
|
GI50 |
0.295 μM
Compound: PU-H71
|
Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
BT-549
|
GI50 |
1.514 μM
Compound: PU-H71
|
Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
CAKI-1
|
GI50 |
0.525 μM
Compound: PU-H71
|
Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
CCRF-CEM
|
GI50 |
0.427 μM
Compound: PU-H71
|
Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
COLO 205
|
GI50 |
0.048 μM
Compound: PU-H71
|
Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
DU-145
|
GI50 |
0.048 μM
Compound: PU-H71
|
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
EKVX
|
GI50 |
2.512 μM
Compound: PU-H71
|
Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HCC 2998
|
GI50 |
0.282 μM
Compound: PU-H71
|
Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HCT-116
|
GI50 |
0.063 μM
Compound: PU-H71
|
Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HCT-15
|
GI50 |
0.437 μM
Compound: PU-H71
|
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HeLa
|
IC50 |
226.5 nM
Compound: 5; PU-H71
|
Antiproliferative activity against human HeLa cells by MTT assay
Antiproliferative activity against human HeLa cells by MTT assay
|
[PMID: 31839539]
|
HL-60(TB)
|
GI50 |
0.063 μM
Compound: PU-H71
|
Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HOP-62
|
GI50 |
0.263 μM
Compound: PU-H71
|
Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HOP-92
|
GI50 |
0.288 μM
Compound: PU-H71
|
Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
Hs-578T
|
GI50 |
1.288 μM
Compound: PU-H71
|
Cytotoxicity against human Hs 578T cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human Hs 578T cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
HT-29
|
GI50 |
0.038 μM
Compound: PU-H71
|
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
IGROV-1
|
GI50 |
0.089 μM
Compound: PU-H71
|
Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
K562
|
GI50 |
0.071 μM
Compound: PU-H71
|
Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
KM12
|
GI50 |
0.059 μM
Compound: PU-H71
|
Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
LOX IMVI
|
GI50 |
0.079 μM
Compound: PU-H71
|
Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
M14
|
GI50 |
0.234 μM
Compound: PU-H71
|
Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
Malme-3M
|
GI50 |
0.123 μM
Compound: PU-H71
|
Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
MCF7
|
IC50 |
0.043 μM
Compound: 5, PU-H71
|
Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay
Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assay
|
[PMID: 18571929]
|
MCF7
|
GI50 |
0.046 μM
Compound: PU-H71
|
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
MCF7
|
IC50 |
0.06 μM
Compound: 5, PU-H71
|
Inhibition of Hsp90 in human MCF7 cells assessed as Her2 level after 24 hrs by Western blot
Inhibition of Hsp90 in human MCF7 cells assessed as Her2 level after 24 hrs by Western blot
|
[PMID: 18571929]
|
MDA-MB-231
|
GI50 |
0.479 μM
Compound: PU-H71
|
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
MDA-MB-435
|
GI50 |
0.091 μM
Compound: PU-H71
|
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
MDA-MB-468
|
GI50 |
0.083 μM
Compound: PU-H71
|
Growth inhibition of human MDA-MB-468 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human MDA-MB-468 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
MDA-MB-468
|
IC50 |
|
Growth inhibition in human breast cancer MDA-MB-468 cell line using SRB
Growth inhibition in human breast cancer MDA-MB-468 cell line using SRB
|
[PMID: 16392823]
|
MOLT-4
|
GI50 |
0.091 μM
Compound: PU-H71
|
Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
NCI/ADR-RES
|
GI50 |
3.631 μM
Compound: PU-H71
|
Cytotoxicity against human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
NCI-H226
|
GI50 |
0.759 μM
Compound: PU-H71
|
Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
NCI-H23
|
GI50 |
0.089 μM
Compound: PU-H71
|
Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
NCI-H322M
|
GI50 |
|
Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
NCI-H460
|
GI50 |
0.058 μM
Compound: PU-H71
|
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
NCI-H522
|
GI50 |
0.059 μM
Compound: PU-H71
|
Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
OVCAR-3
|
GI50 |
0.589 μM
Compound: PU-H71
|
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
OVCAR-4
|
GI50 |
33.113 μM
Compound: PU-H71
|
Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
OVCAR-5
|
GI50 |
|
Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
OVCAR-8
|
GI50 |
0.155 μM
Compound: PU-H71
|
Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
PC-3
|
GI50 |
0.132 μM
Compound: PU-H71
|
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
PC-3
|
IC50 |
363 nM
Compound: 5; PU-H71
|
Antiproliferative activity against human PC3 cells by MTT assay
Antiproliferative activity against human PC3 cells by MTT assay
|
[PMID: 31839539]
|
RPMI-8226
|
GI50 |
1.514 μM
Compound: PU-H71
|
Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
RXF 393
|
GI50 |
0.759 μM
Compound: PU-H71
|
Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SF-268
|
GI50 |
2.089 μM
Compound: PU-H71
|
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SF-295
|
GI50 |
0.145 μM
Compound: PU-H71
|
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SF-539
|
GI50 |
0.851 μM
Compound: PU-H71
|
Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SK-BR-3
|
IC50 |
|
Growth inhibition in human breast cancer SKBr3 cell line using SRB
Growth inhibition in human breast cancer SKBr3 cell line using SRB
|
[PMID: 16392823]
|
SK-MEL-2
|
GI50 |
0.355 μM
Compound: PU-H71
|
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SK-MEL-28
|
GI50 |
0.417 μM
Compound: PU-H71
|
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SK-MEL-5
|
GI50 |
0.457 μM
Compound: PU-H71
|
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SK-OV-3
|
GI50 |
0.045 μM
Compound: PU-H71
|
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SN12C
|
GI50 |
0.174 μM
Compound: PU-H71
|
Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SNB-19
|
GI50 |
0.646 μM
Compound: PU-H71
|
Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SNB-75
|
GI50 |
0.724 μM
Compound: PU-H71
|
Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SR
|
GI50 |
|
Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
SW-620
|
GI50 |
0.059 μM
Compound: PU-H71
|
Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
T47D
|
GI50 |
0.155 μM
Compound: PU-H71
|
Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
TK-10
|
GI50 |
0.162 μM
Compound: PU-H71
|
Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
U-251
|
GI50 |
0.129 μM
Compound: PU-H71
|
Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
UACC-257
|
GI50 |
0.309 μM
Compound: PU-H71
|
Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
UACC-62
|
GI50 |
0.372 μM
Compound: PU-H71
|
Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|
UO-31
|
GI50 |
0.324 μM
Compound: PU-H71
|
Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 27914802]
|