E3 Ligase Ligand-Linker Conjugates

E3 连接酶配体-连接子偶联物是蛋白水解靶向嵌合分子（PROTACs）的一部分，它包含一个 E3 泛素连接酶的配体和一个连接子，与靶蛋白的配体（如 JQ1 连接 BRD4 蛋白，Molibresib 连接 BET 蛋白）连接后，可用于构建靶蛋白泛素化降解的 PROTACs。目前，已发现多种PROTAC通过特异性靶向BET、雌激素受体（ER）、雄激素受体等表现出良好的生物活性。MedChemExpress（MCE）提供各种高质量的E3连接酶配体-接头结合物，包括von Hippel-Lindau（VHL）配体、MDM2配体、Cereblon（CRBN）配体和cIAP1配体与不同的接头（PEG、烷基链、烷基/醚等）结合。设计和合成各种新型PROTAC（ARV-825、dBET1、MT-802等）既方便又省时，可以扩大PROTAC在癌症、自身免疫、炎症和其他疾病治疗中的应用。

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison

E3 Ligase Ligand-Linker Conjugates 相关产品 (685)
抗体 (1)
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

By Effects:	抑制剂 (1) 化学品 (5)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-KT001

E3 Ligase Ligand-Linker Conjugate Kit
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.

HY-111997

VH285-PEG4-C4-Cl	1799506-07-2	≥98.0%
VH285-PEG5-C6-Cl (HaloPROTAC 3) 由 E3 配体与 16 个原子相连的复合分子，连接子的接头为 Halogen 基团。VH285-PEG5-C6-Cl 包含基于 VH285 的 VHL 配体和基于 alkyl/ether linker。VH285-PEG4-C4-Cl 是一种高效的 GFP-HaloTag7 降解剂，DC₅₀ 为 19 nM。VH285-PEG4-C4-Cl 在浓度为 625 nM 时诱导 90% GFP-Halotag 降解。VH285-PEG4-C4-Cl 与 VHL 结合，IC₅₀ 为 0.54 μM。

HY-145449

CC-885-CH2-PEG1-NH-CH3	2722698-03-3	99.22%
CC-885-CH2-PEG1-NH-CH3 是一种新降解剂，可用于合成抗体新降解剂偶联活性分子 (AnDC)。

HY-145448

MC-VC-PABC-amide-PEG1-CH2-CC-885	2722697-82-5	99.93%
MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound III) 是一种 neoDegrader-Linker 偶联物，是 GSPT1 降解剂/分子胶 CC-885 (HY-101488) 和连接子的共轭物。MC-VC-PABC-amide-PEG1-CH2-CC-885 能够偶联特异性靶向 CD56 的抗体 DAR3.7 合成抗体-药物偶联物 (Antibody-Drug Conjugates (ADCs))。

HY-103601

(S,R,S)-AHPC-PEG4-N3	1797406-81-5	99.93%
(S,R,S)-AHPC-PEG4-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 个单元 PEG linker。(S,R,S)-AHPC-PEG4-N3 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

HY-103598

(S,R,S)-AHPC-PEG3-N3	1797406-80-4	99.67%
(S,R,S)-AHPC-PEG3-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。(S,R,S)-AHPC-PEG3-N3 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

HY-167759

Pomalidomide-PEG2-acetic acid	2143097-05-4	98.05%
Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) 是由 E3 连接酶配体和连接子组成的复合物。Pomalidomide-PEG2-acetic acid 可用于 PROTAC 合成。

HY-170901

E3 Ligase Ligand-linker Conjugate 165	2789679-85-0
E3 Ligase Ligand-linker Conjugate 165 是一种 E3 连接酶配体和连接子的偶联物，可用于合成 PROTAC SJ44236 (HY-170900)。

HY-169397

Thalidomide-NH-CH2-CONH-C2-PEG-bromine
Thalidomide-NH-CH2-CONH-C2-PEG-bromine 是 E3 连接酶配体和连接子的偶联物，可以用于合成 PROTAC 降解剂 SK-3-91 (HY-137341)。

HY-130271

(S,R,S)-AHPC-PEG5-COOH	2172820-14-1	99.80%
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 5 个单元 PEG linker。

HY-131717

Thalidomide-NH-CH2-COOH	927670-97-1	98.07%
Thalidomide-NH-CH2-COOH 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-NH-CH2-COOH 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子，例如 THAL-SNS-032 (HY-123937)。

HY-103602

(S,R,S)-AHPC-PEG3-NH2 hydrochloride	2097971-11-2	99.01%
(S,R,S)-AHPC-PEG3-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。

HY-112495

VH032-PEG5-C6-Cl	1799506-06-1	99.93%
VH032-PEG5-C6-Cl (HaloPROTAC 2) 由 E3 配体与 21 个原子相连的复合分子，连接子的接头为 Halogen 基团。VH032-PEG5-C6-Cl (HaloPROTAC 2) 是包含基于 VH032 的 VHL 配体和 5 个单元 PEG linker。VH032-PEG5-C6-Cl 能够诱导 GFP-HaloTag7 降解。

HY-103600

(S,R,S)-AHPC-PEG1-N3	2101200-09-1	98.18%
(S,R,S)-AHPC-PEG1-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。(S,R,S)-AHPC-PEG1-N3 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

HY-152231

BODIPY FL thalidomide	2740620-18-0	99.20%
BODIPY FL thalidomide 是人脑蛋白的高亲和力荧光探针，K_d 值为 3.6 nM。

HY-103603

(S,R,S)-AHPC-PEG2-NH2 hydrochloride	2097973-72-1	99.77%
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker。可用于合成 PROTAC 分子。

HY-125843

Pomalidomide-PEG1-C2-N3	2271036-44-1	99.91%
Pomalidomide-PEG1-C2-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个单元 PEG 的 linker。Pomalidomide-PEG1-C2-N3 可通过 PROTAC 技术合成选择性的 CDK6 降解剂 CP-10。CP-10 诱导 CDK6 降解，DC₅₀ 为 2.1 nM。Pomalidomide-PEG1-C2-N3 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

HY-103604A

(S,R,S)-AHPC-PEG4-NH2	2010159-57-4	99.51%
(S,R,S)-AHPC-PEG4-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 个单元 PEG linker。

HY-141431

Cbl-b-IN-2	2503325-21-9
Cbl-b-IN-2 (Example 8) 是一种口服有效的生物化合物，可抑制泛素蛋白酶体通路中的 E3 酶 Casitas b系淋巴瘤原癌基因-b (Cbl-b)。Cbl-b-IN-2 可用于调节免疫系统和易受免疫系统调节的疾病。Cbl-b-IN-2 (Example 8) 还可单独或与一种或多种免疫检查点抑制剂，抗肿瘤剂和放射剂联合应用于癌症。

HY-103599

(S,R,S)-AHPC-PEG2-N3	2010159-45-0	99.74%
(S,R,S)-AHPC-PEG2-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker。(S,R,S)-AHPC-PEG2-N3 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

HY-141012

Thalidomide-O-PEG4-NHS ester	2411681-88-2
Thalidomide-O-PEG4-NHS ester 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

E3 Ligase Ligand-Linker Conjugates Isoform Comparison

von Hippel-Lindau (VHL)

MDM2

Cereblon

cIAP1

Aryl Hydrocarbon Receptor

TRIM21

E3 Ligase Ligand-Linker Conjugates

Product Name	von Hippel-Lindau (VHL)	MDM2	Cereblon	cIAP1	Aryl Hydrocarbon Receptor	TRIM21	Purity

(S,R,S)-AHPC-PEG4-N3	VHL						99.93%
(S,R,S)-AHPC-PEG3-N3	VHL						99.67%
(S,R,S)-AHPC-PEG5-COOH	VHL						99.80%
Thalidomide-NH-CH2-COOH			Cereblon				98.07%
(S,R,S)-AHPC-PEG3-NH2 hydrochloride	VHL						99.01%
(S,R,S)-AHPC-PEG1-N3	VHL						98.18%
BODIPY FL thalidomide			Cereblon				99.20%
(S,R,S)-AHPC-PEG2-NH2 hydrochloride	VHL						99.77%
Pomalidomide-PEG1-C2-N3			Cereblon				99.91%
(S,R,S)-AHPC-PEG4-NH2	VHL						99.51%
(S,R,S)-AHPC-PEG2-N3	VHL						99.74%
Thalidomide-O-PEG4-NHS ester			Cereblon
Thalidomide-O-amido-PEG4-azide			Cereblon				99.19%
VH032-PEG3-acetylene	VHL						98.14%
Thalidomide-O-PEG2-propargyl			Cereblon				98.26%
Pomalidomide-PEG4-azide			Cereblon				99.85%
Pomalidomide-PEG4-C-COOH			Cereblon				99.10%
A 410099.1, amine-Boc hydrochloride				cIAP1
Pomalidomide-C2-NH2 hydrochloride			Cereblon				99.46%
Pomalidomide 4'-PEG5-acid			Cereblon
Pomalidomide-PEG3-azide			Cereblon				98.88%
(S,R,S)-AHPC-amido-C5-acid	VHL						99.58%
Lenalidomide-C5-NH2 hydrochloride			Cereblon				98.44%
Pomalidomide 4'-alkylC5-acid			Cereblon				98.78%
Thalidomide-4-O-C6-NH2 hydrochloride			Cereblon				98.53%
Pomalidomide-PEG2-azide			Cereblon
Thalidomide-O-amido-C3-COOH			Cereblon				98.43%
Pomalidomide-C7-COOH			Cereblon				98.07%
Thalidomide-PEG2-C2-NH2 hydrochloride			Cereblon				99.89%
Pomalidomide 4'-PEG3-azide			Cereblon
Nutlin-C1-amido-PEG4-C2-N3		MDM2					99.19%
Pomalidomide-PEG4-C2-NH2 hydrochloride			Cereblon
Thalidomide-O-C2-acid			Cereblon
Pomalidomide-PEG1-C2-COOH			Cereblon				99.76%
Biotin-PEG6-Thalidomide			Cereblon				98.51%
(S,R,S)-AHPC-C8-NH2	VHL
Lenalidomide-propargyl-C2-NH2 hydrochloride			Cereblon				98.04%
Thalidomide-O-C8-COOH			Cereblon
Pomalidomide-amido-C3-COOH			Cereblon				99.51%
Thalidomide-NH-PEG3-propionic acid			Cereblon				99.72%
Thalidomide-O-C6-COOH			Cereblon				99.67%
(S,R,S)-AHPC-C3-NH2 hydrochloride	VHL
(S,R,S)-AHPC-PEG4-NH2 hydrochloride	VHL						98.06%
Thalidomide-O-amido-C4-N3			Cereblon				98.36%
Pomalidomide-PEG3-C2-NH2 TFA			Cereblon				99.0%
(S,R,S)-AHPC-Me-C5-COOH	VHL
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride			Cereblon
Thalidomide-NH-PEG4-COOH			Cereblon				98.55%
Pomalidomide-amido-PEG3-C2-NH2			Cereblon				99.55%
Thalidomide-NH-C5-NH2 hydrochloride			Cereblon				99.28%
(S,R,S)-AHPC-C2-NH2 dihydrochloride	VHL						98.63%
Thalidomide-O-C5-acid			Cereblon
Pomalidomide-amino-PEG3-NH2 hydrochloride			Cereblon				99.52%
Thalidomide-NH-C10-COOH			Cereblon
Thalidomide-C2-amido-C2-COOH			Cereblon				98.45%
Pomalidomide-C3-NHS ester			Cereblon				98.70%
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl	VHL						99.89%
Pomalidomide-amino-PEG5-NH2 hydrochloride			Cereblon				99.58%
Thalidomide-propargyl			Cereblon				99.97%
Thalidomide-4-O-C5-NH2 hydrochloride			Cereblon
Lenalidomide-acetylene-C5-COOH			Cereblon				99.26%
Thalidomide-O-C8-Boc			Cereblon
Thalidomide-piperazine-Boc			Cereblon				98.82%
Thalidomide-O-amido-C4-NH2 hydrochloride			Cereblon				98.11%
Thalidomide-Piperazine-PEG1-COOH			Cereblon				99.24%
Thalidomide-NH-PEG2-COOH			Cereblon				98.65%
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride			Cereblon				98.29%
(S,R,S)-AHPC-C4-NH2 dihydrochloride	VHL
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride			Cereblon				98.10%
Thalidomide-Piperazine-PEG3-COOH			Cereblon				99.89%
Thalidomide-PEG2-NH2 hydrochloride			Cereblon
Thalidomide-Piperazine 5-fluoride			Cereblon
Thalidomide-Piperazine 5-fluoride hydrochloride			Cereblon
Lenalidomide-C4-NH2 hydrochloride			Cereblon				98.85%
Thalidomide-4-O-C2-NH2 hydrochloride			Cereblon				99.37%
(S,R,S)-AHPC-C6-NH2	VHL						98.03%
Thalidomide-O-PEG4-azide			Cereblon				98.03%
Pomalidomide-C12-NH2 hydrochloride			Cereblon
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH			Cereblon
Thalidomide-O-amido-C3-NH2 TFA			Cereblon				99.58%
Thalidomide-NH-C6-NH-Boc			Cereblon
Thalidomide-NH-C6-NH2 TFA			Cereblon				99.82%
Thalidomide-NH-PEG2-C2-NH-Boc			Cereblon				98.37%
Thalidomide-O-amido-C6-NH2 TFA			Cereblon				99.82%
Thalidomide-PEG4-NH2 hydrochloride			Cereblon
Thalidomide-O-amido-PEG3-C2-NH2			Cereblon
Thalidomide-Piperazine-PEG1-NH2			Cereblon
(S,R,S)-AHPC-PEG5-Boc	VHL
Thalidomide-PEG2-C2-NH2 TFA			Cereblon				99.39%
Thalidomide-O-amido-C3-PEG3-C1-NH2			Cereblon				99.08%
Pomalidomide-PEG6-NH2 hydrochloride			Cereblon				98.01%
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA			Cereblon				99.28%
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride			Cereblon
Thalidomide-4-O-C4-NH2 hydrochloride			Cereblon				99.35%
Pomalidomide-amido-C1-Br			Cereblon
Thalidomide-O-amido-C4-NH2			Cereblon
Thalidomide-Piperazine-PEG2-NH2			Cereblon
Thalidomide-O-amido-PEG2-C2-NH2 TFA			Cereblon				99.72%
Thalidomide-Piperazine-PEG2-COOH			Cereblon				99.79%
Pomalidomide-PEG4-C2-NH2			Cereblon
Thalidomide-NH-PEG3-COOH			Cereblon				98.90%
(S,R,S)-AHPC-C8-NH2 hydrochloride	VHL
(S,R,S)-AHPC-Me-C10-Br	VHL
(S,R,S)-AHPC-PEG3-NH2	VHL						99.26%
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride	VHL
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2	VHL
Thalidomide-PEG5-COOH			Cereblon				98.09%
(S,R,S)-AHPC-C6-NH2 hydrochloride	VHL
(S,R,S)-AHPC-O-Ph-PEG1-NH2	VHL
(S,R,S)-AHPC-PEG2-NH2	VHL
Thalidomide-PEG3-COOH			Cereblon				98.05%
Thalidomide-PEG4-COOH			Cereblon
Pomalidomide-PEG6-butyl iodide			Cereblon				98.35%
Thalidomide-Propargyne-PEG1-COOH			Cereblon				99.62%
Thalidomide-Propargyne-PEG3-COOH			Cereblon				98.01%
Thalidomide-Propargyne-PEG2-COOH			Cereblon				98.73%
(S,R,S)-AHPC-PEG3-propionic acid	VHL
Pomalidomide-C3-NH2 hydrochloride			Cereblon
Thalidomide-O-amido-C8-NH2 TFA			Cereblon				99.43%
Thalidomide-5-PEG4-NH2 hydrochloride			Cereblon
Thalidomide-Piperazine-Piperidine hydrochloride			Cereblon				98.41%
Pomalidomide-PEG3-C2-NH2			Cereblon
(S,R,S)-AHPC-C4-NH2 hydrochloride	VHL
Thalidomide-4-O-C10-COOH			Cereblon				99.14%
Thalidomide-O-PEG4-amine			Cereblon
Thalidomide-NH-PEG3-NH-Boc			Cereblon
Thalidomide-PEG4-Propargyl			Cereblon
Lenalidomide-C5-amido-Boc			Cereblon
Thalidomide-O-C6-azide			Cereblon				99.71%
Thalidomide-NH-C8-NH2 hydrochloride			Cereblon
Pomalidomide-PEG3-C2-NH2 hydrochloride			Cereblon
Thalidomide-PEG5-NH2 hydrochloride			Cereblon
Glutarimide-Isoindolinone-NH-PEG3-COOH			Cereblon				99.12%
Pomalidomide-PEG4-Ph-NH2			Cereblon				≥98.0%
Thalidomide-5-CH2-NH2 hydrochloride			Cereblon				98.55%
Thalidomide-NH-PEG1-NH2 hydrochloride			Cereblon				99.59%
Thalidomide-O-amido-PEG3-C2-NH2 TFA			Cereblon				99.55%
Thalidomide-NH-C6-NH2 hydrochloride			Cereblon				99.62%
Thalidomide-4-O-C3-NH2 hydrochloride			Cereblon
Thalidomide-5-PEG3-NH2 hydrochloride			Cereblon
Thalidomide-O-PEG4-amine hydrochloride			Cereblon
Thalidomide-O-amido-C4-NH2 TFA			Cereblon				99.92%
Lenalidomide-C5-acid			Cereblon
Pomalidomide-amino-PEG4-NH2			Cereblon
Thalidomide-4-O-C8-NH2 hydrochloride			Cereblon
Thalidomide-O-C6-NHBoc			Cereblon
Glutarimide-Isoindolinone-NH-PEG4-COOH			Cereblon				99.52%
Glutarimide-Isoindolinone-NH-PEG2-COOH			Cereblon				98.51%
(S,R,S)-AHPC-C1-Br	VHL						≥98.0%
Pomalidomide-amino-PEG4-NH2 hydrochloride			Cereblon				99.27%
Thalidomide-Piperazine-PEG2-NH2 diTFA			Cereblon				99.73%
Thalidomide-Piperazine-PEG1-NH2 diTFA			Cereblon				99.43%
Pomalidomide-C4-NH2 hydrochloride			Cereblon				99.24%
cIAP1 Ligand-Linker Conjugates 1				cIAP1
Thalidomide-O-C3-acid			Cereblon
Thalidomide-O-amido-C6-NH2			Cereblon
Thalidomide-4-O-C10-NH2			Cereblon
Thalidomide-4-O-C6-NH2			Cereblon
(S,R,S)-AHPC-C3-NH2 TFA	VHL
Thalidomide-O-amide-C5-NH2			Cereblon
Thalidomide-PEG5-NH2			Cereblon
Thalidomide-O-amido-C3-NH2			Cereblon
Thalidomide-O-amido-C8-NH2 hydrochloride			Cereblon
Thalidomide-O-amido-PEG-C2-NH2			Cereblon
Thalidomide-5-PEG4-NH2			Cereblon
Thalidomide-5-PEG3-NH2			Cereblon
Thalidomide-PEG2-NH2			Cereblon
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride			Cereblon
Thalidomide-O-amido-PEG2-C2-NH2			Cereblon
Thalidomide-4-O-C7-NH2			Cereblon
Thalidomide-O-amide-C5-NH2 TFA			Cereblon
Lenalidomide-PEG3-iodine			Cereblon
Thalidomide-Piperazine-PEG3-NH2			Cereblon
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2			Cereblon
Thalidomide-NH-PEG7			Cereblon
Thalidomide-NH-C2-PEG3-OH			Cereblon
Lenalidomide-C5-NH2 TFA			Cereblon				98.94%
Thalidomide-PEG3-NH2			Cereblon
Thalidomide-Piperazine-Piperidine			Cereblon
(S,R,S)-AHPC-C10-NH2	VHL
Thalidomide-PEG2-C2-NH2			Cereblon
Thalidomide-4-O-C8-NH2			Cereblon
Thalidomide-4-O-C6-NH2 TFA			Cereblon
Thalidomide-NH-PEG4-MS			Cereblon
Thalidomide-NH-C4-NH2 TFA			Cereblon
Thalidomide-NH-C6-NH2			Cereblon
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride			Cereblon
(S,R,S)-AHPC-C8-NH2 dihydrochloride	VHL
Pomalidomide-PEG2-Tos			Cereblon
(S,R,S)-AHPC-C6-NH2 dihydrochloride	VHL
Thalidomide-NH-C4-NH-Boc			Cereblon				99.64%
(S,R,S)-AHPC-PEG1-OTs	VHL
(S,R,S)-AHPC-C3-NH2	VHL
VHL Ligand-Linker Conjugates 15	VHL
(S,R,S)-AHPC-C5-COOH	VHL						98.81%
(S,R,S)-AHPC-C10-NH2 dihydrochloride	VHL
(S,R,S)-AHPC-PEG1-NH2 dihydrochloride	VHL
(S,R,S)-AHPC-Me-C10-NH2	VHL
Pomalidomide-amido-C3-piperazine-N-Boc			Cereblon
Thalidomide-O-amido-PEG4-C2-NH2			Cereblon
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc			Cereblon
Pomalidomide-amido-C4-amido-C6-NH-Boc			Cereblon
(S,R,S)-AHPC-C4-NH2	VHL
Pom-8PEG			Cereblon
Thalidomide-O-C11-acid			Cereblon
Thalidomide-O-C4-NH2			Cereblon
Thalidomide-4-O-C5-NH2			Cereblon
Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride			Cereblon
Thalidomide-NH-amido-PEG1-C2-NH2			Cereblon
Thalidomide-5-NH-PEG2-NH2 hydrochloride			Cereblon
Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride			Cereblon
cIAP1 Ligand-Linker Conjugates 2				cIAP1
(S,R,S)-AHPC-C2-NH2	VHL
Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride			Cereblon
Thalidomide-NH-amido-C4-NH2 hydrochloride			Cereblon
(S,R,S)-AHPC-C7-amine	VHL
Thalidomide-O-PEG4-Boc			Cereblon
Thalidomide-4-C3-NH2 hydrochloride			Cereblon
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc			Cereblon
Thalidomide-NH-CH2-COO(t-Bu)			Cereblon
Thalidomide-NH-amido-C8-NH2 hydrochloride			Cereblon
Thalidomide-NH-amido-PEG4-C2-NH2			Cereblon
Thalidomide-NH-amido-C6-NH2			Cereblon
Thalidomide-O-amido-C6-NH2 hydrochloride			Cereblon				99.32%
Thalidomide-NH-amido-C3-NH2			Cereblon
Pomalidomide-C4-NH2			Cereblon
Thalidomide-N-C3-O-C4-O-C3-OH			Cereblon
cIAP1 Ligand-Linker Conjugates 3				cIAP1
Thalidomide-NH-amido-C3-NH2 hydrochloride			Cereblon
VHL Ligand-Linker Conjugates 17	VHL
cIAP1 Ligand-Linker Conjugates 4				cIAP1
Boc-A 410099.1 amide-alkylC4-amine				cIAP1
(S,R,S)-AHPC-PEG1-NH2	VHL
Thalidomide-O-CH2-CO-NH-C2-PEG2-NH-Boc			Cereblon
Pomalidomide-amino-PEG3-NH2			Cereblon
(S,R,S)-AHPC-C1-NH2	VHL
Thalidomide-NH-C5-NH2			Cereblon
Thalidomide-NH-PEG8-Ts			Cereblon
Thalidomide-NH-C8-NH2			Cereblon
cIAP1 Ligand-Linker Conjugates 5				cIAP1
AhR Ligand-Linker Conjugates 1					Aryl Hydrocarbon Receptor
Amino-PEG6-Thalidomide			Cereblon
A 410099.1, amine-Boc				cIAP1
Thalidomide-4-O-CH2-COO(t-Bu)			Cereblon
cIAP1 Ligand-Linker Conjugates 6 hydrochloride				cIAP1
Pomalidomide-C6-NHS ester			Cereblon
Acepromazine-1-Piperazinepropanamine						TRIM21
Pomalidomide-cyclopentane-amide-Alkyne			Cereblon
cIAP1 Ligand-Linker Conjugates 15 hydrochloride				cIAP1
(S,R,S)-AHPC-C1-NH2 hydrochloride	VHL						98.08%
Pomalidomide-C3-NH2			Cereblon
Thalidomide-amido-PEG2-NH2 hydrochloride			Cereblon
Thalidomide-NH-amido-C5-NH2			Cereblon
cIAP1 Ligand-Linker Conjugates 7				cIAP1
Thalidomide-4-O-C2-NH2			Cereblon
(S,R,S)-AHPC-C5-NH2	VHL
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride			Cereblon
Thalidomide-O-C3-NH2			Cereblon
cIAP1 Ligand-Linker Conjugates 8				cIAP1
cIAP1 Ligand-Linker Conjugates 9				cIAP1
cIAP1 Ligand-Linker Conjugates 10				cIAP1
Thalidomide-NH-PEG1-NH2			Cereblon
Thalidomide-O-PEG4-amine TFA			Cereblon
cIAP1 Ligand-Linker Conjugates 11				cIAP1
cIAP1 Ligand-Linker Conjugates 12				cIAP1
A 410099.1 amide-PEG3-amine-Boc				cIAP1
Thalidomide-NH-amido-PEG2-C2-NH2			Cereblon
Thalidomide-NH-amido-C5-NH2 hydrochloride			Cereblon
Thalidomide-O-C7-acid			Cereblon				98.55%
(S,R,S)-AHPC-C2-PEG4-N3	VHL
Thalidomide-NH-amido-C4-NH2			Cereblon
Thalidomide-PEG3-NH2 hydrochloride			Cereblon				98.02%
cIAP1 Ligand-Linker Conjugates 13				cIAP1
A 410099.1 amide-PEG2-amine-Boc				cIAP1
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH	VHL						99.31%
cIAP1 Ligand-Linker Conjugates 14				cIAP1
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride				cIAP1
Thalidomide-4-NH-PEG1-NH2 TFA			Cereblon
Thalidomide-O-C4-COOH			Cereblon
Thalidomide-5-PEG2-Cl			Cereblon
cIAP1 Ligand-Linker Conjugates 15				cIAP1
Thalidomide-NH-amido-C2-NH2			Cereblon
Thalidomide-NH-PEG1-NH2 diTFA			Cereblon
Thalidomide-NH-amido-C2-NH2 hydrochloride			Cereblon
Thalidomide-NH-(CH2)2-NH2 TFA			Cereblon
Thalidomide-piperidine-C2-piperazine-Boc			Cereblon
N-Boc-SBP-0636457-O-C3-COOH				cIAP1
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride				cIAP1
Thalidomide-O-amido-PEG4-propargyl			Cereblon
Thalidomide-5-propargyne-NH2 hydrochloride			Cereblon
Thalidomide-NH-amido-PEG3-C2-NH2			Cereblon
Thalidomide-NH-amido-C8-NH2			Cereblon
Thalidomide-amido-PEG2-NH2			Cereblon
Thalidomide-5-propoxyethanamine			Cereblon
Thalidomide-NH-amido-C6-NH2 hydrochloride			Cereblon
Pomalidomide-amino-PEG5-NH2			Cereblon
Pomalidomide 4'-PEG6-azide			Cereblon
Thalidomide-piperazine-piperidine-2-F-Ph-CHO			Cereblon
Pomalidomide-PEG3-OH			Cereblon
Pomalidomide-PEG2-OH			Cereblon
Pomalidomide-C2-acid			Cereblon
Ethanolamine-Thalidomide-4-OH			Cereblon
Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride			Cereblon
Thalidomide-O-amido-C8-NH2			Cereblon
VH032-thiol-C6-NH2	VHL

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