TGF-β Receptor Inhibitors

ALK1

ALK2

ALK3

ALK4

ALK5

ALK6

ALK7

TGFβR2

ACVR2A

ACVR2B

TGF-β Receptor Degraders & Inhibitors

Product Name	ALK1	ALK2	ALK3	ALK4	ALK5	ALK6	ALK7	TGFβR2	ACVR2A	ACVR2B	Purity
SB-431542				ALK4, IC₅₀: 1 μM	ALK5, IC₅₀: 0.75 μM		ALK7, IC₅₀: 2 μM				99.85%
Dorsomorphin		ACVR1	BMPR1A			ALK6					99.91%
A 83-01				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM				99.41%
Dorsomorphin dihydrochloride		ACVR1	BMPR1A			ALK6					99.91%
LDN193189		ACVR1, IC₅₀: 5 nM	BMPR1A, IC₅₀: 30 nM								99.48%
RepSox					ALK5, IC₅₀: 4 nM						99.92%
Bimagrumab									ACVR2A, Kd: 434 pM	ACVR2B, Kd: 1.7 pM	99.23%
LDN193189 Tetrahydrochloride		ACVR1, IC₅₀: 5 nM	BMPR1A, IC₅₀: 30 nM								99.86%
Vactosertib					ALK5, IC₅₀: 12.9 nM						99.58%
A 83-01 sodium				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM				98.43%
LDN-212854	ALK1, IC₅₀: 2.4 nM	ACVR1, IC₅₀: 1.3 nM	BMPR1A, IC₅₀: 85.8 nM	ALK4, IC₅₀: 2133 nM	ALK5, IC₅₀: 9276 nM						99.70%
R-268712					TGFBR1, IC₅₀: 2.5 nM						99.88%
ML347	ALK1, IC₅₀: 46 nM	ACVR1, IC₅₀: 32 nM	BMPR1A, IC₅₀: 10800 nM								99.94%
Sotatercept									ACVR2A		99.61%
OD36		ACVR1, Kd: 37 nM ACVR1, IC₅₀: 47 nM ALK2 R206H, IC₅₀: 22 nM									98.70%
Vactosertib Hydrochloride					ALK5, IC₅₀: 12.9 nM						99.09%
SB-431542 (GMP)				ALK4, IC₅₀: 1 μM	ALK5, IC₅₀: 0.75 μM		ALK7, IC₅₀: 2 μM
IN-1130					ALK5						99.79%
EW-7195					ALK5, IC₅₀: 4.83 nM						99.20%
AZ12799734	ALK1, Kd: 7.1 μM	ACVR1, Kd: 6.2 μM	BMPR1A, Kd: 40 μM	ALK4, Kd: 1 μM	ALK5, Kd: 0.74 μM TGFBR1, IC₅₀: 47 nM	ALK6, Kd: 0.017 μM					98.07%
Itacnosertib		ACVR1			ALK5						99.06%
AZ12601011				ALK4			ALK7				99.88%
Zilurgisertib		ALK2									99.77%
ALK2-IN-2		ACVR1, IC₅₀: 9 nM									99.56%
KER047 succinate		ACVR1									98.93%
KER047		ACVR1									99.35%
THRX-144644					ALK5, IC₅₀: 0.14 nM						99.90%
ALK5-IN-34					ALK5, IC₅₀: <10 nM						98.21%
TGFBR1-IN-1					ALK5, IC₅₀: 10-100 nM
ALK5-IN-33					ALK5, IC₅₀: ≤10 nM
MU1700	ALK1, IC₅₀: 13 nM	ALK2, IC₅₀: 6 nM				ALK6, IC₅₀: 41 nM
ALK5-IN-27					ALK5, IC₅₀: ≤10 nM
OD36 hydrochloride		ACVR1, Kd: 37 nM ACVR1, IC₅₀: 47 nM ALK2 R206H, IC₅₀: 22 nM
J-1149					ALK5, IC₅₀: 0.017 μM
ALK5-IN-28					ALK5, IC₅₀: ≤10 nM
TGFβRII-IN-3								TGF-βR2, IC₅₀: 4.1 μM
M4K2281		ALK2, IC₅₀: 2 nM			ALK5, IC₅₀: 350 nM
ALK5-IN-25					ALK5, IC₅₀: ≤10 nM
J-1063					ALK5
TGFβRII-IN-2								TGF-βR2, IC₅₀: 2.4 μM
M4K2306		ALK2, IC₅₀: 7 nM			ALK5, IC₅₀: 3915 nM

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