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  3. Isotope-Labeled Compounds
  4. Acalabrutinib-d3

Acalabrutinib-d3  (Synonyms: ACP-196-d3)

目录号: HY-W757743
产品使用指南

摩尔计算器

Acalabrutinib-d3 (ACP-196-d3) 是 Acalabrutinib (HY-17600) 的氘代物。Acalabrutinib (ACP-196) 是一种具有口服活性，不可逆的，高度选择性的第二代 BTK 抑制剂。Acalabrutinib 与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。Acalabrutinib 在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。

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Acalabrutinib-d<sub>3</sub> Chemical Structure

Acalabrutinib-d3 Chemical Structure

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规格 是否有货
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Acalabrutinib-d3 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

分子量

468.53

Formula

C26H20D3N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Acalabrutinib-d3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acalabrutinib-d3ACP-196-d3Isotope-Labeled CompoundsChronic lymphocytic leukemiaCLLInhibitorinhibitorinhibit

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