2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. ADC Control Human IgG1-vcMMAE (solution)

ADC Control Human IgG1-vcMMAE (solution) 

目录号: HY-164153 纯度: 98.03%
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ADC Control Human IgG1-vcMMAE (solution) 是一种人源单克隆抗体，是 ADC human IgG1-vcMMAE 的同型对照，并且可以抑制微管蛋白聚合。其中抗体部分是 Human IgG1 kappa, Isotype Control (HY-P99001)，ADC 毒性分子和 linker 部分是 VcMMAE (HY-15575)。

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ADC Control Human IgG1-vcMMAE (solution)

ADC Control Human IgG1-vcMMAE (solution) Chemical Structure

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ADC Control Human IgG1-vcMMAE (solution) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADC Control Human IgG1-vcMMAE (solution) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAE and can inhibit tubulin polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is vcMMAE (HY-15575)[1].

体外研究
(In Vitro)

VcMMAE (MMAE) 在 CD30+ 癌细胞内从 SGN-35 有效释放，并且由于其膜渗透性，能够对旁观者细胞发挥细胞毒活性[1]。MMAE 以与有丝分裂停滞相关的时间表和剂量依赖性方式使结直肠癌细胞和胰腺癌细胞对 IR 敏感。放射增敏作用表现为受照射细胞中克隆形成存活率下降和 DNA 双链断裂增加[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ADC Control Human IgG1-vcMMAE (solution) 相关抗体:
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADC Control Human IgG1-vcMMAE (solution) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADC Control Human IgG1-vcMMAE (solution)Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug Conjugatesisotype controlADC human IgG1tubulinvcMMAEInhibitorinhibitorinhibit

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ADC Control Human IgG1-vcMMAE (solution)
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