2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ALK5-IN-10

ALK5-IN-10 (Compound 5d) 是一种 TGF-β I型受体激酶 (ALK5) 抑制剂，对于 ALK5 和 p38α 的 IC50 分别为 0.007 和 1.98 μM。ALK5-IN-10 能够用于癌症的研究。

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ALK5-IN-10 Chemical Structure

ALK5-IN-10 Chemical Structure

CAS No. : 1352608-94-6

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ALK5-IN-10 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK5-IN-10 (Compound 5d) is a TGF-β type I receptor kinase ALK5 inhibitor, with IC50s of 0.007 and 1.98 μM for ALK5 and p38α, respectively. ALK5-IN-10 can be used for the research of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
0.007 μM
Compound: 12d
Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assay
Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assay
[PMID: 24786585]
分子量

460.33

Formula

C22H18BrN7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK5-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK5-IN-101352608-94-6TGF-β ReceptorTransforming growth factor beta receptorsp38αcancerTGF-βInhibitorinhibitorinhibit

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产品名称：
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目录号：
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