2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. ALRT1550

ALRT1550 (LGD1550) 是一种选择性视黄酸受体 (RAR) 激动剂，能够以极高的效力结合 RARs，Kd 值约为 1-4 nM。ALRT1550 具有抗增殖活性，在 UMSCC-22B 鳞状细胞癌细胞中，ALRT1550 的 IC50 值为 0.22 nM。在小鼠肿瘤异种移植模型中，ALRT1550 剂量依赖性地抑制肿瘤生长，抑制率最高达 89%。ALRT1550 可用于癌症领域研究。

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ALRT1550 Chemical Structure

ALRT1550 Chemical Structure

CAS No. : 178600-20-9

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ALRT1550 相关抗体

Top Publications Citing Use of Products

查看 RAR/RXR 亚型特异性产品:

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RXRα RXRβ RXRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALRT1550 (LGD1550) is a selective retinoic acid receptor (RAR) agonist that binds RARs with exceptional potency, with Kd values of approximately 1-4 nM. ALRT1550 exhibits anti-proliferative activity, with an IC50 value of 0.22 nM in UMSCC-22B squamous carcinoma cells. In a mouse tumor xenograft model, ALRT1550 inhibited tumor growth in a dose-dependent manner, achieving a maximum inhibition rate of 89%. ALRT1550 is applicable for research in the field of cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ME-180 IC50
1 nM
Compound: 5; ALRT1550
Antiproliferative activity against human ME-180 cells assessed as inhibition of cell growth by [3H]-thymidine incorporation based liquid scintillation counter analysis
Antiproliferative activity against human ME-180 cells assessed as inhibition of cell growth by [3H]-thymidine incorporation based liquid scintillation counter analysis
[PMID: 33895500]
分子量

340.50

Formula

C23H32O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALRT1550 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALRT1550178600-20-9LGD1550ALRT 1550ALRT-1550LGD 1550LGD-1550RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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目录号：
HY-106963
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