2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. AMG-151

AMG-151 (ARRY-403)是一种葡萄糖激酶激动剂，具有降低空腹血糖（FPG）活性。AMG-151在随机、安慰剂对照的IIa期研究中显示出与安慰剂相比，具有显著的线性剂量效应趋势。AMG-151的使用与低血糖和高三酸甘油脂的较高发生率相关。AMG-151可作为抑制1型糖尿病的潜在化合物。

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AMG-151 Chemical Structure

AMG-151 Chemical Structure

CAS No. : 1138669-65-4

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AMG-151 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes[1].

分子量

454.53

Formula

C20H18N6O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMG-151 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-1511138669-65-4ARRY-403AMG151AMG 151ARRY403ARRY 403Endogenous MetaboliteInhibitorinhibitorinhibit

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目录号：
HY-125316
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