2. Anti-infection Apoptosis
  3. Bacterial TNF Receptor
  4. Anti-inflammatory agent 11

Anti-inflammatory agent 11 (化合物 16) 是一种有效的抗结核分枝杆菌和抗炎剂。Anti-inflammatory agent 11 抑制 Mtb H37Rv 和 M299 生长，其 MIC50 (最低抑制浓度 50%) 分别为 1.3 和 6.9 μM。Anti-inflammatory agent 11 通过抑制 iNOS 表达抑制 NO，同时抑制 TNF-α 和 IL-1β 的产生。Anti-inflammatory agent 11 可用于结核病的研究。

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Anti-inflammatory agent 11 Chemical Structure

Anti-inflammatory agent 11 Chemical Structure

CAS No. : 63932-07-0

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Anti-inflammatory agent 11 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].

IC50 & Target

MIC50: 1.3 ± 1.1 μM (Mtb H37Rv), 6.9 ± 0.8 μM (Mtb M299); IC50: 7.4 ± 1.1 μM (NO)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
≥ 200 μM
Compound: 16
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
18.7 μM
Compound: 16
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
7.4 μM
Compound: 16
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
[PMID: 34890996]
RAW264.7 CC50
93.2 μM
Compound: 16
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 34890996]
体外研究
(In Vitro)

Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 11 相关抗体:
分子量

286.35

Formula

C14H14N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 1163932-07-0BacterialTNF ReceptorTumor Necrosis Factor ReceptorTNFRthiourea derivativeantimycobacterialanti-inflammatorylow cytotoxicityTuberculosisTBMtb H37RvMtb M299MycobacteriumbacterialInhibitorinhibitorinhibit

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