2. Anti-infection
  3. Bacterial
  4. Antitubercular agent-31

Antitubercular agent-31 (Compound 2) 是一种抗结核剂，抑制 M. tuberculosis H37Rv 的 MIC 为 0.03 μM。Antitubercular agent-31 也抑制 DprE1，IC50 为 1.1 μM。

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Antitubercular agent-31 Chemical Structure

Antitubercular agent-31 Chemical Structure

CAS No. : 2764818-29-1

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Antitubercular agent-31 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM[1].

IC50 & Target

IC50: 1.1 μM (DprE1)[1]
体外研究
(In Vitro)

Antitubercular agent-31 (Compound 2) shows aqueous solubility of 0.81 μg/mL in phosphate buffer pH 7.4. The plasma protein binding property is 97.9%[1].
Antitubercular agent-31 shows acceptable liver microsomal stability in human and mouse liver microsomes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitubercular agent-31 相关抗体:
体内研究
(In Vivo)

Antitubercular agent-31 (10 or 2 mg/kg; p.o. or i.v.; once) displays an acceptable pharmacokinetics (PK) profile with only dosing i.v., shows either poor membrane permeability or rapid clearance rate in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c mice[1]
Dosage: 10 mg/kg or 2 mg/kg
Administration: Oral (10 mg/kg) or intravenous (2 mg/kg) administration (Pharmacokinetic Analysis)
Result: PK data for Antitubercular agent-31 (Compound 2),iv, 2mg/kg[1].
Tmax (h) Cmax (ng/mL) AUC0-t
(h*ng/mL)		 AUC0-∞
(h*ng/mL)		 T1/2 (h) CL/F
(mL/h/kg)		 MRT0-∞
(h)
0.1±0.0 463.4±103.4 158.2±18.8 161.3±18.6 0.3±0.0 12515.5±1379.7 0.4±0.0

No compound signal was detected at oral administration.
分子量

502.56

Formula

C20H24F2N4O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitubercular agent-31 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitubercular agent-312764818-29-1Antitubercular agent31Antitubercular agent 31BacterialantitubercularM. tuberculosisH37RvDprE1Inhibitorinhibitorinhibit

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