2. Anti-infection
  3. Bacterial
  4. Antituberculosis agent-9

Antituberculosis agent-9 (Compound 5a) 是一种具有口服活性的抗结核剂，对 H37Ra 的 MIC 为 0.5 μg/mL。

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Antituberculosis agent-9 Chemical Structure

Antituberculosis agent-9 Chemical Structure

CAS No. : 2998587-72-5

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Antituberculosis agent-9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra[1].

体外研究
(In Vitro)

Antituberculosis agent-9 (Compound 5a; 48 h) 显示出对 HepG2 细胞的细胞毒性，IC50 值为 3.1 μM[1]。
Antituberculosis agent-9 (6 days) 对 MRSA、M. abscessus 和 M. smegmatis 有抑制作用，MIC 均为 4.0 μg/mL[1]。
Antituberculosis agent-9 (6 days) 对临床分离的 M. tuberculosis 有抑制作用。对 H37Rv、K4、K12、K5、K16 的 MIC 值分别为 0.5、0.5、0.5、1.0 和 1.0 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antituberculosis agent-9 相关抗体:
体内研究
(In Vivo)

Antituberculosis agent-9 (Compound 5a; 300 mg/kg; oral; daily for 4 days) 对小鼠有中等抗结核作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice, autoluminescent Mtb infection model[1]
Dosage: 300 mg/kg
Administration: Oral administration, daily for 4 days
Result: There was a relative light unit (RLU) reduction of 0.5 log10 in live mice, compared to the control group (CMC-Na).
Animal Model: Sprague-Dawley rats[1]
Dosage: 5 or 15 mg/kg
Administration: IV or PO (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of Antituberculosis agent-9 (Compound 5a) In Vivo[1]
cpd. administration Cmax (μg/L) Tmax (h) T1/2 (h) Clz (L/h/kg) AUC0-t (μg/L•h) F %
Antituberculosis agent-9 (Compound 5a) iv (5 mg/kg) 595 ± 62 26.2 ± 0.9 1.5 ± 0.3 1694 ± 201
po (15 mg/kg) 108 ± 18 >24 2079 ± 274 40.7
分子量

436.98

Formula

C25H29ClN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antituberculosis agent-9 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antituberculosis agent-92998587-72-5Antituberculosis agent9Antituberculosis agent 9BacterialH37RaHepG2MRSAM. abscessusM. smegmatisM. tuberculosisH37RvInhibitorinhibitorinhibit

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