2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Aspochalasin I

Aspochalasin I 对癌细胞 NCIH460、MCF-7 和 SF-268 表现出细胞毒性，IC50 分别为 22.1、33.4 和 19.9 μM。Aspochalasin I 通过抑制酪氨酸酶 (tyrosinase)，抑制黑色素生成 (IC50 为 22.4 μM)，因此可用作美白剂。

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Aspochalasin I Chemical Structure

Aspochalasin I Chemical Structure

CAS No. : 670225-69-1

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Aspochalasin I 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
33.4 μM
Compound: 1, aspochalasin I
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 15043404]
NCI-H460 IC50
22.1 μM
Compound: 1, aspochalasin I
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
[PMID: 15043404]
SF-268 IC50
19.9 μM
Compound: 1, aspochalasin I
Cytotoxicity against human SF268 cells after 48 hrs by MTT assay
Cytotoxicity against human SF268 cells after 48 hrs by MTT assay
[PMID: 15043404]
分子量

417.54

Formula

C24H35NO5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aspochalasin I 相关分类

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Keywords:

Aspochalasin I670225-69-1TyrosinaseNCIH460MCF-7SF-268Mel-Ab melanocyteInhibitorinhibitorinhibit

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