2. Apoptosis Epigenetics Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Ferroptosis Epigenetic Reader Domain Reactive Oxygen Species (ROS) Glutathione Peroxidase
  4. ATF3-IN-1

ATF3-IN-1 是一种铁死亡 (ferroptosis) 和 ATF3 抑制剂。ATF3-IN-1 通过 ATF3/SLC7A11/GPX4 通路抑制氧化应激和铁死亡 (ferroptosis)，发挥抗缺血性中风作用。ATF3-IN-1 可以减轻缺血/再灌注 (I/R) 损伤并提高神经元存活率。ATF3-IN-1 具有神经保护作用，可用于研究缺血性中风。

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ATF3-IN-1

ATF3-IN-1 Chemical Structure

CAS No. : 2952703-90-9

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ATF3-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATF3-IN-1 is a ferroptosis and ATF3 inhibitor. ATF3-IN-1 inhibits oxidative stress and ferroptosis through the ATF3/SLC7A11/GPX4 pathway, exerting anti-ischemic stroke effects. ATF3-IN-1 can attenuate ischemia/reperfusion (I/R) injury and improve neuronal survival. ATF3-IN-1 has neuroprotective effects and can be used to study ischemic stroke[1].

体外研究
(In Vitro)

ATF3-IN-1 (Compound 1c) (0.1-2 μM) 通过抑制原代皮质神经元缺氧-葡萄糖剥夺 (OGD) 模型中的氧化应激和铁死亡来缓解 I/R 损伤[1]。

ATF3-IN-1 (0.1-2 μM) 对没有 OGD 的大鼠皮质神经元没有细胞毒性[1]。

ATF3-IN-1 通过 ATF3/SLC7A11/GPX4 轴在原代皮质神经元 OGD 模型中减轻铁死亡并减少 I/R 损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATF3-IN-1 相关抗体:
体内研究
(In Vivo)

ATF3-IN-1 (Compound 1c) (2 mg/kg，ICV，一次给药) 通过调节大鼠大脑中动脉闭塞 (MCAO) 模型中的 ATF3/SLC7A11/GPX4 轴，氧化应激和铁死亡，减少梗死体积，促进脑 I/R 损伤后的神经功能恢复[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (250 g, Six-week-old) MCAO model[1]
Dosage: 2 mg/kg
Administration: ICV, once
Result: Inhibited ATF3 expression and reduces ROS production, Upregulated SLC7A11 and GPX4 expression.
分子量

451.55

Formula

C24H37NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATF3-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATF3-IN-12952703-90-9FerroptosisEpigenetic Reader DomainReactive Oxygen Species (ROS)Glutathione PeroxidaseInhibitorIschemic strokeOGD modelsMCAO modelinhibitorinhibit

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