2. Autophagy Cell Cycle/DNA Damage Neuronal Signaling
  3. Autophagy CDK Atg8/LC3 PINK1/Parkin
  4. Autophagy agonist-1

Autophagy agonist-1 (compound 22) 一种自噬 (Autophagy) 激动剂。Autophagy agonist-1 对HepG2 细胞和正常细胞表现出显著的抗癌活性，其 IC50 值分别为 8.8 μM和 > 50 μM。Autophagy agonist-1 诱导 G1/S 期细胞周期阻滞，并抑制 CDK4 和 CyclinD1 的表达，同时上调 P21。Autophagy agonist-1 促进自噬体和蛋白质 LC3 及 PINK1 的积累，增强 HepG2 细胞中的自噬和线粒体自噬。

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Autophagy agonist-1 Chemical Structure

Autophagy agonist-1 Chemical Structure

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Autophagy agonist-1 相关抗体

Top Publications Citing Use of Products

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

生物活性

Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells[1].

IC50 & Target[1]

CDK4

 

分子量

559.70

Formula

C33H41N3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Autophagy agonist-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy agonist-1Autophagy agonist1Autophagy agonist 1AutophagyCDKAtg8/LC3PINK1/ParkinCyclin dependent kinaseAutophagy-related 8| 20-Deoxyingenol derivativesCytotoxicityA549HepG2 cell linesanticancer activityInhibitorinhibitorinhibit

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Autophagy agonist-1
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