Bisdemethoxycucurmin (Synonyms: 双去氧基姜黄素; Curcumin III; Didemethoxycurcumin)

目录号: HY-N0007A 纯度: 98.96%: FAQs
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Bisdemethoxycucurmin (Curcumin III) 是一种姜黄素，具有抗氧化和抗炎活性。

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Bisdemethoxycucurmin Chemical Structure

CAS No. : 24939-16-0

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥203	In-stock
1 mg	￥149	In-stock
5 mg	￥300	In-stock
10 mg	￥450	In-stock
25 mg	￥861	In-stock
50 mg	￥1350	In-stock
100 mg	￥1980	In-stock
500 mg	￥4950	In-stock
1 g		询价
5 g		询价

or 大包装询价

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Customer Review

Other Forms of Bisdemethoxycucurmin:

Bisdemethoxycucurmin (Standard) 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Bisdemethoxycucurmin (Curcumin III), a curcuminoid, has antioxidant and antiinflammatory activities^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-431	IC₅₀	> 100 μM Compound: BDC	Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC₅₀	38.1 μM Compound: Bisdemethoxycurcumin	Cytotoxicity against human A549 cells after 72 hrs by crystal violet staining based microplate reader analysis Cytotoxicity against human A549 cells after 72 hrs by crystal violet staining based microplate reader analysis	[PMID: 23153397]
Caco-2	IC₅₀	> 100 μM Compound: 1b	Cytotoxicity against human Caco2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human Caco2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of undifferentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of undifferentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of differentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of differentiated human Caco2 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of undifferentiated human Caco2 cells measured after 72 hrs by SRB assay Growth inhibition of undifferentiated human Caco2 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
Caco-2	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of differentiated human Caco2 cells measured after 72 hrs by SRB assay Growth inhibition of differentiated human Caco2 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
CHO-K1	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of CHOK1 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of CHOK1 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
CHO-K1	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of CHOK1 cells measured after 72 hrs by SRB assay Growth inhibition of CHOK1 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
CHO-K1	IC₅₀	91.4 μM Compound: 1b	Cytotoxicity against CHOK1 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against CHOK1 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
DLD-1	IC₅₀	> 40 μM Compound: BDC	Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
EA.hy 926	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human EAhy926 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of human EAhy926 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
EA.hy 926	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human EAhy926 cells measured after 72 hrs by SRB assay Growth inhibition of human EAhy926 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
EA.hy 926	IC₅₀	54.3 μM Compound: 1b	Cytotoxicity against human EAhy926 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human EAhy926 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
EOL1	IC₅₀	22.3 μM Compound: 4	Cytotoxicity against human EOL-1 cells after 48 hrs by MTT assay Cytotoxicity against human EOL-1 cells after 48 hrs by MTT assay	[PMID: 24689857]
HEK293	EC₅₀	200 μM Compound: 3	Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay	[PMID: 20004045]
HepG2	IC₅₀	> 100 μM Compound: 1b	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
HepG2	IC₅₀	62.9 μM Compound: Bisdemethoxycurcumin	Cytotoxicity against human HepG2 cells after 72 hrs by crystal violet staining based microplate reader analysis Cytotoxicity against human HepG2 cells after 72 hrs by crystal violet staining based microplate reader analysis	[PMID: 23153397]
HepG2	IC₅₀	75.5 μM Compound: 1c	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 26894841]
HT-29	IC₅₀	> 100 μM Compound: 1b	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27843113]
HT-29	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human HT-29 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay Growth inhibition of human HT-29 cells assessed as mitochondrial activity measured after 72 hrs by MTT assay	[PMID: 27521589]
HT-29	IC₅₀	> 25 μM Compound: 1b; BDMC	Growth inhibition of human HT-29 cells measured after 72 hrs by SRB assay Growth inhibition of human HT-29 cells measured after 72 hrs by SRB assay	[PMID: 27521589]
KB	IC₅₀	21.44 μM Compound: 3	Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay	[PMID: 24857542]
KB	CC₅₀	8.5 μM Compound: 11c	Compound concentration required to reduce the exponential growth of KB cells by 50% Compound concentration required to reduce the exponential growth of KB cells by 50%	[PMID: 9767632]
LNCaP	IC₅₀	19.7 μM Compound: 2	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF7	IC₅₀	24.3 μM Compound: 2	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF7	IC₅₀	48.9 μM Compound: BDC	Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
MDA-MB-231	IC₅₀	11 mM Compound: BDMC	Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA	[PMID: 31336310]
MDA-MB-231	IC₅₀	21.9 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 19249204]
MDA-MB-231	IC₅₀	24 μM Compound: bisdemethoxycurcumin	Inhibition of TGF-beta-induced PTHrP secretion in human MDA-MB-231 cells treated 4 hrs before TGF-beta challenge measured after 24 hrs by radioimmunoassay Inhibition of TGF-beta-induced PTHrP secretion in human MDA-MB-231 cells treated 4 hrs before TGF-beta challenge measured after 24 hrs by radioimmunoassay	[PMID: 23145932]
MDA-MB-231	IC₅₀	38.5 μM Compound: Bisdemethoxycurcumin	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by crystal violet staining based microplate reader analysis Cytotoxicity against human MDA-MB-231 cells after 72 hrs by crystal violet staining based microplate reader analysis	[PMID: 23153397]
MT4	CC₅₀	13 μM Compound: 11c	Compound concentration required to reduce the exponential growth of MT-4 cells by 50% Compound concentration required to reduce the exponential growth of MT-4 cells by 50%	[PMID: 9767632]
PC-12	ED₅₀	2 μg/mL Compound: 5, bisdemethoxycurcumin	Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay	[PMID: 12350137]
PC-12	ED₅₀	3.5 μg/mL Compound: 5, bisdemethoxycurcumin	Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay	[PMID: 12350137]
PC-3	IC₅₀	27.3 μM Compound: 2	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 19249204]
WRL68	IC₅₀	45.4 μM Compound: BDC	Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]

分子量

308.33

Formula

C₁₉H₁₆O₄

CAS 号

24939-16-0

性状

固体

颜色

Light yellow to orange

中文名称

双去氧基姜黄素

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 66.67 mg/mL (216.23 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2433 mL	16.2164 mL	32.4328 mL
5 mM	0.6487 mL	3.2433 mL	6.4866 mL
10 mM	0.3243 mL	1.6216 mL	3.2433 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.96%

选择批次：

Data Sheet (591 KB) SDS (393 KB)

COA (258 KB) HNMR (277 KB) RP-HPLC (262 KB) MS (69 KB)

产品使用指南 (1538 KB)

参考文献

[1]. M Kuroyanagi, et al. [Some observation on curcuminoids from Zingiberaceae plants]. Yakugaku Zasshi. 1970 Nov;90(11):1467-70. [Content Brief]

[2]. Toshiya Masuda, et al. Antioxidative and Antiinflammatory Compounds from Tropical Gingers: Isolation, Structure Determination, and Activities of Cassumunins A, B, and C, New Complex Curcuminoids from Zingiber cassumunar. J. Agric. Food Chem. 1994, 42, 9,

Bisdemethoxycucurmin 相关分类

Inflammation/Immunology

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2433 mL	16.2164 mL	32.4328 mL	81.0820 mL
	5 mM	0.6487 mL	3.2433 mL	6.4866 mL	16.2164 mL
	10 mM	0.3243 mL	1.6216 mL	3.2433 mL	8.1082 mL
	15 mM	0.2162 mL	1.0811 mL	2.1622 mL	5.4055 mL
	20 mM	0.1622 mL	0.8108 mL	1.6216 mL	4.0541 mL
	25 mM	0.1297 mL	0.6487 mL	1.2973 mL	3.2433 mL
	30 mM	0.1081 mL	0.5405 mL	1.0811 mL	2.7027 mL
	40 mM	0.0811 mL	0.4054 mL	0.8108 mL	2.0270 mL
	50 mM	0.0649 mL	0.3243 mL	0.6487 mL	1.6216 mL
	60 mM	0.0541 mL	0.2703 mL	0.5405 mL	1.3514 mL
	80 mM	0.0405 mL	0.2027 mL	0.4054 mL	1.0135 mL
	100 mM	0.0324 mL	0.1622 mL	0.3243 mL	0.8108 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisdemethoxycucurmin24939-16-0Curcumin III Didemethoxycurcumin双去氧基姜黄素OtherscurcuminoidantioxidantantiinflammatoryInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Bisdemethoxycucurmin (Synonyms: 双去氧基姜黄素; Curcumin III; Didemethoxycurcumin)

Customer Review

Other Forms of Bisdemethoxycucurmin: