2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor
  4. Blonanserin dihydrochloride

Blonanserin dihydrochloride  (Synonyms: AD-5423 dihydrochloride)

目录号: HY-13575A
产品使用指南

摩尔计算器

Blonanserin dihydrochloride 是一种有效的 5-HT2A 和多巴胺 D2 受体拮抗剂，其 Ki 分别为0.812 和0.142 nM。Blonanserin dihydrochloride 通常作为一种非典型的抗精神病剂，可用于锥体外系症状、过度镇静或低血压的研究。

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Blonanserin dihydrochloride Chemical Structure

Blonanserin dihydrochloride Chemical Structure

CAS No. : 132812-45-4

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Blonanserin dihydrochloride 的其他形式现货产品:

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Other Forms of Blonanserin dihydrochloride:

Blonanserin dihydrochloride 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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α adrenergic receptor β adrenergic receptor

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Sigma 1 Receptor Sigma 2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Blonanserin dihydrochloride is a potent and orally active 5-HT2A and dopamine D2 receptor antagonist, with Ki values of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension[1][2].

IC50 & Target

D2 Receptor

0.142 nM (Ki)

D3 Receptor

0.494 nM (Ki)

D4 Receptor

150 nM (Ki)

D1 Receptor

1070 nM (Ki)

5-HT2A Receptor

0.812 nM (Ki)

5-HT2C Receptor

26.4 nM (Ki)

5-HT6 Receptor

11.7 nM (Ki)

α1-adrenergic receptor

26.7 nM (Ki)

α2-adrenergic receptor

530 nM (Ki)

体外研究
(In Vitro)

Blonanserin dihydrochloride exerts some blockade of α1-adrenergic receptors (Ki=26.7 nM) and also shows significant affinity for the D3 receptor (Ki=0.494 nM). Blonanserin dihydrochloride possesses low affinity for the sigma receptor (IC50=286 nM), but lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Blonanserin dihydrochloride 相关抗体:
体内研究
(In Vivo)

Blonanserin dihydrochloride (Oral gavage; 1 mg/kg; once a day for 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice received saline or phencyclidine once a day for 14 consecutive days[2]
Dosage: 1 mg/kg
Administration: Oral gavage; once a day for 14 days
Result: Had an effect on the social deficit in mice that received repeated PCP administration.
Clinical Trial
分子量

440.42

Formula

C23H32Cl2FN3
CAS 号
中文名称

盐酸布南色林 d8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Blonanserin dihydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blonanserin132812-45-4AD-5423盐酸布南色林 d8AD5423AD 54235-HT ReceptorDopamine ReceptorAdrenergic ReceptorSigma ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorantipsychoticschizophrenia.?extrapyramidal symptomexcessive?sedationhypotensionsocial deficitInhibitorinhibitorinhibit

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