2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Cav 3.2 inhibitor 4

Cav 3.2 inhibitor 4 (compound 21) 是一种有效的外周限制性选择性 T 型钙通道 (Cav3.2) 抑制剂，IC50 值为 0.6 μM。Cav 3.2 inhibitor 4 可用于心房颤动的研究。

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Cav 3.2 inhibitor 4 Chemical Structure

Cav 3.2 inhibitor 4 Chemical Structure

CAS No. : 1416984-93-4

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Cav 3.2 inhibitor 4 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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  • 参考文献

生物活性

Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Cav3.2) inhibitor, with an IC50 of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
> 31.6 μM
Compound: 21
Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay
Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay
[PMID: 23200256]
CHO IC50
> 33 μM
Compound: 21
Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay
Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay
[PMID: 23200256]
CHO IC50
> 33 μM
Compound: 21
Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay
Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay
[PMID: 23200256]
CHO IC50
> 33 μM
Compound: 21
Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay
Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay
[PMID: 23200256]
CHO IC50
> 33 μM
Compound: 21
Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay
Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay
[PMID: 23200256]
CHO IC50
> 33 μM
Compound: 21
Inhibition of human ERG expressed in CHO cells by IONWORKS assay
Inhibition of human ERG expressed in CHO cells by IONWORKS assay
[PMID: 23200256]
HEK293 IC50
0.6 μM
Compound: 21
Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay
Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay
[PMID: 23200256]
分子量

459.41

Formula

C21H32Cl2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cav 3.2 inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cav 3.2 inhibitor 41416984-93-4Calcium ChannelCa2+ channelsCa channelsT-typeatrial fibrillationInhibitorinhibitorinhibit

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目录号：
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