2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK1-IN-5

CDK1-IN-5 (10h) 是 CDK1 的选择性抑制剂，对 CDK1，CDK2 和 CDK5 的 IC50 值分别为 42.19，188.71 和 354.15 nM。CDK1-IN-5 通过影响细胞周期抑制癌细胞生长。CDK1-IN-5 可用于癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK1-IN-5 Chemical Structure

CDK1-IN-5 Chemical Structure

CAS No. : 3032997-20-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CDK1-IN-5 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK1-IN-5 (10h) is a selective CDK1 inhibitor with IC50s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer[1].

IC50 & Target

CDK1

42.19 nM (IC50)

CDK2

188.71 nM (IC50)

CDK5

354.15 nM (IC50)

体外研究
(In Vitro)

CDK1-IN-5 (0-10 μM; 24 h) inhibits the growth of various cancer cells[1].
CDK1-IN-5 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 42.19, 188.71 and 354.15 nM, respectively[1].
CDK1-IN-5 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5649, 8945, 2538, 2417, 8546 and 8138 nM, respectively[1].
CDK1-IN-5 (0.73 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK1-IN-5 相关抗体:

Cell Proliferation Assay[1]

Cell Line: PDAC, melanoma, leukemia, colon, and breast cancer cell lines
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Inhibited cell growth of PDAC, melanoma, leukemia, colon and breast cancer cells over 62%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.73 and 1 μM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.73 μM
Incubation Time: 24 hours
Result: Downregulated the CDK1 protein level compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.73 μM
Incubation Time: 24 hours
Result: Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
分子量

504.05

Formula

C27H26ClN5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK1-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1-IN-53032997-20-6CDKCyclin dependent kinasephthalazineanticancerpancreaticderivativecell cyclePDACmelanomaleukemiacolonbreastcancerMDA-PATC53Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CDK1-IN-5
目录号：
HY-151409
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z