2. Cell Cycle/DNA Damage Apoptosis
  3. CDK MDM-2/p53
  4. CDK2/MDM2-IN-1

CDK2/MDM2-IN-1 (III-13) 是一种 CDK2/MDM2 双重抑制剂，对 CDK2 的 IC50 值为 2.60 nM。CDK2/MDM2-IN-1 具有抗肿瘤活性。

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CDK2/MDM2-IN-1 Chemical Structure

CDK2/MDM2-IN-1 Chemical Structure

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CDK2/MDM2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC50 value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity[1].

体外研究
(In Vitro)

CDK2/MDM2-IN-1 (100, 200 nM, 4 h) 通过 CDK2/p-Rb 和 MDM2/p53 途径抑制肿瘤细胞的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2/MDM2-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT116, OVCAR3
Concentration: 100, 200 nM
Incubation Time: 4 h
Result: Reduced the expression of p-Rb, downstream of CDK2.
Inhibited MDM2 protein expression and elevated p53 expression.
体内研究
(In Vivo)

CDK2/MDM2-IN-1 (25, 50 mg/kg, 腹腔注射, 连续 14 天) 能显著抑制小鼠结肠肿瘤细胞的增殖，且不影响小鼠体重[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A nude mouse model of HCT116 transplanted tumor[1]
Dosage: 25, 50 mg/kg
Administration: i.p. for 14 days
Result: Reduced tumor volume and weight.
分子量

479.57

Formula

C26H33N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2/MDM2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2/MDM2-IN-1CDKMDM-2/p53Cyclin dependent kinaseCDK2MDM2InhibitorAntitumorHCT116OVCAR3inhibitorinhibit

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